B7-H1 AND SURVIVIN IN CANCER
First Claim
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1. A method of determining the prognosis of a subject with cancer, said method comprising:
- (a) providing a tissue sample from said subject; and
(b) assessing in said tissue sample the presence or absence of expression of B7-H1 and survivin, wherein the presence of expression of B7-H1 and survivin in said tissue sample indicates said subject is more likely to die of the cancer than if B7-H1 and survivin expression is absent or B7-H1 or survivin is singly expressed in the tissue sample.
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Abstract
Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination.
130 Citations
21 Claims
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1. A method of determining the prognosis of a subject with cancer, said method comprising:
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(a) providing a tissue sample from said subject; and (b) assessing in said tissue sample the presence or absence of expression of B7-H1 and survivin, wherein the presence of expression of B7-H1 and survivin in said tissue sample indicates said subject is more likely to die of the cancer than if B7-H1 and survivin expression is absent or B7-H1 or survivin is singly expressed in the tissue sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of determining risk of cancer progression in a subject with cancer, said method comprising:
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(a) providing a tissue sample from said subject; and (b) assessing in said tissue sample the presence or absence of expression of B7-H1 and survivin, wherein the presence of expression of B7-H1 and survivin in said tissue sample indicates said subject is at more risk of cancer progression than if B7-H1 and survivin expression is absent or B7-H1 or survivin is singly expressed in the tissue sample. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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- 19. An article of manufacture, said article of manufacture comprising a first antibody that binds to a B7-H1 polypeptide and a second antibody that binds to a survivin polypeptide.
Specification