Small Volume In Vitro Sensor and Methods of Making
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Accused Products
Abstract
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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Citations
43 Claims
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1-11. -11. (canceled)
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12. An integrated piercing and analyte testing device, comprising:
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a housing defining an aperture, wherein the housing comprises; a piercing member adapted to pierce and retract through the aperture and pierce a site on a subject to cause blood to flow therefrom; an analyte sensing member configured to receive a sample of blood from the site on the subject through the aperture and optically determine the concentration of the analyte in the sample; and a display for displaying the concentration of the analyte in the sample. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. An integrated piercing and glucose testing device, comprising:
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a housing defining an aperture, wherein the housing comprises; a piercing member comprising a lancet adapted to pierce and retract through the aperture and pierce a site on a subject to cause blood to flow therefrom; an glucose sensing member comprising an optical glucose test strip configured to receive a sample of blood from the site on the subject through the aperture and optically determine the concentration of the glucose in the sample; sample transport member for transporting the sample from the site on the subject through the aperture to the optical glucose test strip; and a display for displaying the concentration of the glucose in the sample; wherein the lancet and the optical glucose test strip are provided in a single disposable cartridge. - View Dependent Claims (38, 39, 40, 41, 42, 43)
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Specification