APPARATUS AND METHOD FOR NEURAL-SIGNAL CAPTURE TO DRIVE NEUROPROSTHESES OR CONTROL BODILY FUNCTION

• US 20100016732A1
• Filed: 07/17/2009
• Published: 01/21/2010
• Est. Priority Date: 07/17/2008
• Status: Abandoned Application

• Current Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Bendett, Mark P., Wells, Jonathon D.
• Application Number:
  US12/505,462
• Publication Number:
  US 20100016732A1
• Time in Patent Office: Days
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4029 for evaluating the peripheral nervous systems A61B5/24 takes precedence
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/407 Evaluating the spinal cord A61B5/4896 takes precedence
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence
• CPC Class Codes: G01N 2201/0612 Laser diodes
• CPC Class Codes: G06F 3/015 Input arrangements based on nervous system activity detection, e.g. brain waves [EEG] detection, electromyograms [EMG] detection, electrodermal response detection

Abstract

Method and apparatus for detecting nerve activity of an animal. Some embodiments include outputting a light pulse having a wavelength onto a volume of animal tissue such that the light pulse interacts with active nerves of the tissue; measuring a light signal resulting from the interaction of the light pulse with the tissue; transmitting an electrical signal based on the measured light signal; signal-processing the electrical signal; and outputting a response signal, which can optionally be used to control a prosthetic device, stimulate another nerve, or display/ diagnose a condition. Some embodiments output a plurality of light wavelengths and/or pulses, which are optionally high-frequency intensity modulated. Some embodiments analyze DC, AC, and phase components of signals to spatially resolve locations of neural activity. Some embodiments output light pulse(s) and detect the resultant light from outside a human skull to detect neural activity of human brain tissue inside the skull.

Claims

1. An apparatus comprising:

at least one light source, the at least one light source configured to output a light pulse having a wavelength onto a volume of human tissue;

at least one light detector configured to receive light reflected and transmitted by the volume of human tissue and to transmit an electrical signal, wherein the light reflected and transmitted by the volume of human tissue provides an indication of neural activity; and

a signal-processing unit operatively coupled to the at least one light detector and configured to receive and signal-process the electrical signal from the at least one light detector and to output a signal based on the signal-processed electrical signal from the at least one light detector.

2. The apparatus of claim 1, wherein the at least one light source includes a vertical-cavity surface-emitting laser (VCSEL).

3. The apparatus of claim 1, wherein the at least one light source includes a plurality of light sources, wherein the plurality of light sources includes a one-dimensional array of vertical-cavity surface-emitting lasers (VCSELs), and wherein the at least one light detector includes a plurality of light detectors, one or more of the plurality of light detectors corresponding to each of the plurality of light sources.

4. The apparatus of claim 1, wherein the at least one light source includes a micro-light-emitting diode (micro-LED).

5. The apparatus of claim 1, wherein the light pulse traverses through the skin layer, the skull layer, and the dura layer before encountering the neuronal tissue of the human brain.

6. The apparatus of claim 1, wherein the at least one light source is embedded into the skull layer and the light pulse traverses through at least a portion of the skull layer and through the entire dura layer before encountering the neuronal tissue of the human brain.

7. The apparatus of claim 1, wherein the volume of human tissue includes neuronal tissue of a human brain.

8. The apparatus of claim 1, wherein the volume of human tissue includes neuronal tissue of a human spinal cord.

9. The apparatus of claim 1, wherein the at least one light source includes a plurality of light sources and the at least one light detector includes a plurality of light detectors, wherein the plurality of light sources and the plurality of light detectors are arranged circumferentially around the volume of human tissue such that the plurality of lights sources alternates with the plurality of light detectors around the volume of human.

10. The apparatus of claim 1, further comprising the prosthetic device, wherein the output unit is configured to output a response signal to a prosthetic device.

11. A method comprising:

outputting a light pulse having a wavelength onto a volume of human tissue such that the light pulse interacts with the volume of human tissue;

detecting neural signal activity by measuring a resulting light signal from the interaction;

transmitting an electrical signal based on the measured light signal;

processing the electrical signal to generate a response signal; and

outputting the response signal to a prosthetic device based on the processing of the electrical signal to effect an action by the prosthetic device.

12. The method of claim 11, wherein the outputting of the light pulse is done outside a skull of a human and the volume of animal tissue includes human brain tissue inside the skull of the human.

13. The method of claim 11, wherein the outputting of the light pulse includes emitting light at a wavelength of about 675 nm to about 850 nm from a vertical-cavity surface-emitting laser (VCSEL).

14. The method of claim 11, wherein the outputting of the light pulse includes emitting light at a wavelength between about 675 nm to about 850 nm from a micro-light-emitting diode (micro-LED).

15. The method of claim 11, wherein the light pulse traverses through the skin layer, the skull layer, and the dura layer and interacts with neuronal tissue of a human brain.

16. The method of claim 11, wherein the outputting of the light pulse includes outputting a substantially square light pulse having a duration between about 1 ps and about 10 ps.

17. The method of claim 11, wherein the outputting of the light pulse includes outputting a substantially square light pulse having a duration between about 10 ps and about 100 ps.

18. The method of claim 11, wherein the outputting of the light pulse includes intensity-modulating the light pulse at a frequency between about 50 MHz and about 1000 MHz.

19. The method of claim 18, wherein the intensity-modulated light pulse has a duration in a range of between about 10 ns and about 1000 ns.

20. The method of claim 11, wherein the outputting of the light pulse is done from at least one light source is embedded into the skull layer and the light pulse traverses through at least a portion of the skull layer and through the entire dura layer and then interacts with neuronal tissue of a human brain.

21. An apparatus comprising:

means for outputting a light pulse having a wavelength onto a volume of human tissue such that the light pulse interacts with the volume of human tissue;

means for detecting neural signal activity by measuring a resulting light signal from the interaction and for transmitting an electrical signal based on the measured light signal;

means for processing the electrical signal to generate a response signal; and

means for outputting the response signal to a prosthetic device based on the processing of the electrical signal to effect an action by the prosthetic device.

22. The apparatus of claim 21, further comprising the prosthetic device.

23. The apparatus of claim 21, wherein the means for outputting of the light pulse includes a vertical-cavity surface-emitting laser (VCSEL) that emits light at laser light at a wavelength of about 675 nm to about 850 nm.

24. The apparatus of claim 21, wherein the means for outputting of the light pulse includes means for intensity modulating the light pulse at a frequency between about 50 MHz and about 1000 MHz.

25. The apparatus of claim 24, wherein the intensity-modulated light pulse has a duration in a range of between about 10 ns and about 1000 ns.