APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION
First Claim
1. A medical device for use in a body, comprising:
- a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals;
a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas; and
a controller to communicate with the sensing circuit and to control the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to myocardial strain changes.
1 Assignment
0 Petitions
Accused Products
Abstract
A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for different purposes. The system delivers electrical stimulation to modulate myocardial strain for anti-atherosclerosis therapy and/or to provide therapy for myocardial infarction (MI). In one embodiment, a medical device for treating atherosclerosis is provided. The medical device includes a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals. The device also includes a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas. According to various embodiments, a controller communicates with the sensing circuit and controls the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to induce myocardial strain changes. The stimulation is targeted to attenuate or prevent atherosclerosis associated with the CAD, according to various embodiments.
73 Citations
24 Claims
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1. A medical device for use in a body, comprising:
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a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals; a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas; and a controller to communicate with the sensing circuit and to control the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to myocardial strain changes. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method, comprising:
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monitoring a sensed signal from a vessel; identifying areas of coronary artery disease (CAD) or areas at risk for CAD in a myocardium using the sensed signal; and applying electrical stimulation to a region in the myocardium adjacent to the identified areas, the stimulation applied intermittently to induce periods of stretch on the vessel due to myocardial strain changes, the stimulation targeted to provide a therapeutic effect. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. A method, comprising:
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delivering pacing pulses to a first electrode according to an IPT algorithm; sensing a signal indicative of an incidence and location of ischemia or myocardial infarction; detecting the incidence and location of ischemia or myocardial infarction; terminating the delivery of the pacing pulses according to the IPT algorithm if the first electrode is at least a specified distance away from the infarct location to prevent rupture; initiating post-conditioning therapy to treat the location of ischemia or myocardial infarction; delivering pacing pulses to a second electrode within a specified distance from the location of ischemia or myocardial infarction; sensing a parameter indicative of an amount of healing of the wound at the location of ischemia or myocardial infarction; and upon determining the parameter has reached a predetermined threshold to indicate a level of healing at the wound location, resuming the delivery of the pacing pulses to the first electrode according to the IPT algorithm. - View Dependent Claims (18, 19, 20, 21)
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22. A medical device for use in a body, comprising:
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a sensing circuit adapted to receive sensed signals indicative of an incidence and location of ischemia or myocardial infarction and to detect the incidence and location of ischemia or myocardial infarction, and further adapted to sense a parameter indicative of an amount of healing at the location of ischemia or myocardial infarction; a cardiac pacing lead, including a first electrode placed a specified distance away from the infarct location; and a second electrode placed nearer the location of ischemia or myocardial infarction than the first electrode; a pacemaker circuit connected to the pacing lead, the pacing circuit adapted to deliver an electrical signal at a programmed level for a programmed duration; and a controller to communicate with the sensing circuit and to control the pacemaker circuit to provide electrical stimulation through the first electrode to deliver IPT, through the second electrode to deliver post-conditioning therapy subsequent to sensing an incidence of ischemia or myocardial infarction, and, subsequent to sensing a programmable threshold amount of healing, through the first electrode to resume delivery IPT. - View Dependent Claims (23, 24)
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Specification