BLOOD MONITORING SYSTEM

• US 20100020309A1
• Filed: 10/06/2009
• Published: 01/28/2010
• Est. Priority Date: 09/29/2004
• Status: Abandoned Application

• Current Assignee: Intellectual Inspiration, LLC
• Original Assignee: Intellectual Inspiration, LLC
• Inventors: Pesach, Gidon, Pesach, Benny, Shreve, Eric, GOLDBERGER, Daniel, Siebrecht, Wayne, Bitton, Gabriel, Nagar, Ron
• Application Number:
  US12/574,642
• Publication Number:
  US 20100020309A1
• Time in Patent Office: Days
• US Class Current: 356/40
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150366 Blood collection bags, e.g. connected to the patient by a catheter comprising means for removing a small sample of collected blood from the bag collection bags as such A61J1/05, A61M1/0209
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150862 intermediate range, e.g. within room or building
• CPC Class Codes: A61B 5/15087 short range, e.g. between console and disposable using implanted devices A61B5/150877
• CPC Class Codes: A61B 5/150946 Means for varying, regulating, indicating or limiting the speed or time of blood collection
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 5/14232 : Roller pumps
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/40 : relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 40/63 : for local operation

Abstract

The present invention is directed towards apparatuses and methods for the automated measurement of blood analytes and blood parameters for bedside monitoring of patient blood chemistry. Particularly, the current invention discloses a programmable system that can automatically draw blood samples at a suitable programmable time frequency (or at predetermined timing), can automatically analyze the drawn blood samples and immediately measure and display blood parameters such as glucose levels, hematocrit levels, hemoglobin blood oxygen saturation, blood gases, lactate or any other blood parameter.

Claims

1. A system for periodically monitoring at least one parameter of blood comprising:

a fluid channel system connectable to an access device configured to access blood in a patient;

at least one pump configured to draw blood from a patient and transport blood through the fluid channel system;

a plurality of test substrates contained in a housing;

a dispenser system configured to dispense a portion of a blood sample from the fluid channel system to at least one of the plurality of test substrates;

a first sensor configured to analyze the blood sample on at least one of the plurality of test substrates and produce a first sensor signal indicative of a first blood parameter;

a second sensor positioned near the fluid channel system and configured to provide a second sensor signal corresponding to an optical property of a fluid in the fluid channel system, and indicative of a second blood parameter;

wherein information corresponding to the first sensor signal and information corresponding to the second sensor signal are used to provide an improved measurement of a patient fluid parameter; and

a controller configured to control the system to automatically periodically draw a blood sample from a patient into the fluid channel system, to dispense a sample from the patient line to at least one of the plurality of test substrates, to sense an optical property with the second sensor, and to determine a measurement of a patient fluid parameter.

2. The system of claim 1 wherein the second sensor comprises an optical sensor.

3. The system of claim 1 wherein the first blood parameter comprises a glucose level.

4. The system of claim 3 wherein the first blood parameter comprises a whole blood glucose level.

5. The system of claim 1 wherein the second blood parameter comprises a blood gas level.

6. The system of claim 1 wherein the second blood parameter comprises a hemoglobin oxygenation level.

7. The system of claim 1 wherein the second blood parameter comprises a hematocrit level.

8. The system of claim 1 wherein the second blood parameter comprises a glucose level.

9. The system of claim 1 wherein the second blood parameter comprises one or more of a blood glucose level, ketone level, hemoglobin level, lactate level, electrolyte level, blood gas level, cholesterol level, or bilirubin level.

10. The system of claim 1 wherein the first blood parameter comprises one or more of a blood glucose level, ketone level, hemoglobin level, lactate level, electrolyte level, blood gas level, cholesterol level, or bilirubin level.

11. A system for periodically monitoring at least one parameter of blood comprising:

a fluid channel system connectable to an access device configured to access blood in a patient;

at least one pump configured to draw blood from a patient and transport blood through the fluid channel system;

a plurality of test substrates contained in a housing;

a dispenser system configured to dispense a portion of a blood sample from the fluid channel system to at least one of the plurality of test substrates;

a first sensor configured to analyze the blood sample on at least one of the plurality of test substrates and produce a first sensor signal indicative of a first blood parameter;

a second sensor positioned near the fluid channel system and configured to provide a second sensor signal corresponding to an optical property of a fluid in the fluid channel system, and indicative of a second blood parameter

wherein information corresponding to the first sensor signal produces a measurement and information corresponding to the second sensor signal is used to adjust the measurement to provide an improved measurement of a patient fluid parameter; and

a controller configured to control the system to automatically periodically draw a blood sample from a patient into the fluid channel system, to dispense a sample from the patient line to at least one of the plurality of test substrates, to sense an optical property with the second sensor, and to determine a measurement of a patient fluid parameter.

12. The system of claim 11 wherein the second sensor comprises an optical sensor.

13. The system of claim 11 wherein the first blood parameter comprises a glucose level.

14. The system of claim 13 wherein the first blood parameter comprises a whole blood glucose level.

15. The system of claim 11 wherein the second blood parameter comprises a blood gas level.

16. The system of claim 11 wherein the second blood parameter comprises a hemoglobin oxygenation level.

17. The system of claim 11 wherein the second blood parameter comprises a Hematocrit level.

18. The system of claim 11 wherein the second blood parameter comprises a glucose level.

19. The system of claim 11 wherein the second blood parameter comprises one or more of a blood glucose level, ketone level, hemoglobin level, lactate level, electrolyte level, blood gas level, cholesterol level, or bilirubin level.

20. The system of claim 11 wherein the first blood parameter comprises one or more of a blood glucose level, ketone level, hemoglobin level, lactate level, electrolyte level, blood gas level, cholesterol level, or bilirubin level.