NITRIC OXIDE GEL APPARATUS AND METHOD
First Claim
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1. An apparatus comprising a first gel layer disposed on a substrate;
- a substrate non-reactive with the gel layer, and providing a substantially constant area;
the composition further comprising an active ingredient selected from citric acid, ascorbic acid, and potassium nitrite;
an adhesive layer secured to the substrate opposite the first gel layer;
a backing material secured to the adhesive to prevent the adhesive from contacting its environment;
a second gel layer disposed on a second substrate, the second substrate maintaining the second gel layer for interfacing with the first gel layer;
at least one sealing layer to separate the first gel layer and the second gel layer from one another, and from their environment; and
the second gel layer further comprising a second reactant formulated to react with a first reactant disposed within the first gel layer, the second reactant selected from a group consisting of citric acid, ascorbic acid, and potassium nitrite.
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Abstract
Gel strips containing reactants capable of reacting to form nitric oxide are maintained separate until application. Upon application, the gel strips are placed in contact with one another, and may mix, or operate by diffusion, to deliver nitric oxide directly to the stream of breathing air of a user. Adhesive strips bonded to a substrate supporting the gel strips may provide for securing the nitric oxide generator directly to an upper lip of a user for breathing the nitric oxide through the nostrils.
45 Citations
2 Claims
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1. An apparatus comprising a first gel layer disposed on a substrate;
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a substrate non-reactive with the gel layer, and providing a substantially constant area; the composition further comprising an active ingredient selected from citric acid, ascorbic acid, and potassium nitrite; an adhesive layer secured to the substrate opposite the first gel layer; a backing material secured to the adhesive to prevent the adhesive from contacting its environment; a second gel layer disposed on a second substrate, the second substrate maintaining the second gel layer for interfacing with the first gel layer; at least one sealing layer to separate the first gel layer and the second gel layer from one another, and from their environment; and the second gel layer further comprising a second reactant formulated to react with a first reactant disposed within the first gel layer, the second reactant selected from a group consisting of citric acid, ascorbic acid, and potassium nitrite.
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2. A method for inhalation therapy of a user the method comprising providing reactants capable of producing nitric oxide;
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providing a substrate; providing a gel for disposition on the substrate; mixing the reactants into the gel in separate compositions, the first reactant being provided in a first portion of the gel, and second reaction being provided in the second portion of the gel; forming lay ups comprising layers containing an adhesive layer, a substrate layer, a first gel layer, a second gel layer, a second substrate, and a plurality of sealing layers separating the gel layers from one another, and protecting the gel layers of the layers from their surrounding environments; sealing the lay ups; delivering the lay ups to a user; unsealing the adhesive; unsealing the gel layers; exposing the first gel layer to the second gel layer in permanent relation to activate a reaction between the active ingredients therein; positioning the adhesive layer proximate a user to expose the nostrils of a user to nitric oxide generated by the lay up in an activated condition; removing and discarding the lay up upon completion of at least one of expiration of the reaction between reactants, and a preselected time of application selected for a dosing.
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Specification