FUSED HETEROCYCLES
First Claim
1. A method of treating pain in a subject, said method comprising administering to said subject a therapeutically effective amount of a D-amino oxidase inhibitor having the formula:
- in whichR1 is a member selected from the group consisting of H, and substituted or unsubstituted arylalkyl;
R2 is a member selected from the group consisting of H, and substituted or unsubstituted arylalkyl; and
R4 is a member selected from OH and O−
X+whereinX+ is a positive ion which is a member selected from organic positive ions and inorganic positive ions,whereinsubstituted or unsubstituted arylalkyl has the formula;
in whichAr is substituted or unsubstituted aryl; and
n is an integer from 1 to 4.
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Accused Products
Abstract
This invention provides fused heterocycles having the formula:
in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3 is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula:
in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.
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Citations
20 Claims
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1. A method of treating pain in a subject, said method comprising administering to said subject a therapeutically effective amount of a D-amino oxidase inhibitor having the formula:
-
in which R1 is a member selected from the group consisting of H, and substituted or unsubstituted arylalkyl; R2 is a member selected from the group consisting of H, and substituted or unsubstituted arylalkyl; and R4 is a member selected from OH and O−
X+wherein X+ is a positive ion which is a member selected from organic positive ions and inorganic positive ions, wherein substituted or unsubstituted arylalkyl has the formula; in which Ar is substituted or unsubstituted aryl; and n is an integer from 1 to 4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 18, 19, 20)
R2 is H; and R4 is a member selected from OH and O−
X+wherein X+ is a positive ion which is a member selected from organic positive ions and inorganic positive ions.
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19. The method according to claim 18 wherein said pain is neuropathic pain.
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20. The method according to claim 19 wherein said neuropathic pain is a member selected from diabetic peripheral neuropathic pain and post-herpetic neuralgia.
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10. A method of treating pain in a subject, said method comprising administering to said subject a therapeutically effective amount of a D-amino oxidase inhibitor as a pharmaceutical composition comprising, in single or divided doses, a pharmaceutically acceptable carrier and a daily dosage of about 0.1 mg to about 7000 mg of said D-amino oxidase inhibitor, said D-amino oxidase inhibitor having the formula:
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in which R1 is a member selected from the group consisting of H, and substituted or unsubstituted arylalkyl; R2 is a member selected from the group consisting of H, and substituted or unsubstituted arylalkyl; and R4 is a member selected from OH and O−
X+wherein X+ is a positive ion which is a member selected from organic positive ions and inorganic positive ions, wherein substituted or unsubstituted arylalkyl has the formula; in which Ar is substituted or unsubstituted aryl; and n is an integer from 1 to 4. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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Specification