Methods based on fluctuations in cortical synchronization
First Claim
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1. A method of identifying a site of brain injury in a pediatric patient comprising the steps of:
- a) obtaining an electroencephalogram signal on the patient; and
b) evaluating phase synchronization of the signal obtained, wherein a determination of synchrony in the signal of at least 2 standard deviations greater than the mean synchrony of a control is indicative of a site of brain injury.
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Abstract
A method of identifying a site of injury in a pediatric patient with brain injury is provided which comprises obtaining an electroencephalogram signal on the patient. The identification of phase synchrony within the signal is indicative of the site of brain injury. Electroencephalogram signals may also be used to determine prognosis of a pediatric patient in a coma in which an increase in the temporal variability of phase synchronized EEG signals over time is indicative of an improvement in the patient.
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Citations
18 Claims
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1. A method of identifying a site of brain injury in a pediatric patient comprising the steps of:
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a) obtaining an electroencephalogram signal on the patient; and b) evaluating phase synchronization of the signal obtained, wherein a determination of synchrony in the signal of at least 2 standard deviations greater than the mean synchrony of a control is indicative of a site of brain injury. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of prognosis in a pediatric patient in a coma comprising the steps of:
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a) obtaining a first electroencephalogram signal on the patient subsequent to the onset of coma; b) obtaining a second electroencephalogram signal on the patient at a time subsequent to obtaining the first signal; c) evaluating phase synchronization patterns in the first and second signals, or in a portion of the first and second signals; and
.d) calculating the temporal variability of the synchronized patterns, wherein increased variability in the signal over time is indicative of an improvement in the patient. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of monitoring the prognosis of a pediatric patient in a coma comprising the steps of:
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a) obtaining an electroencephalogram signal on the patient at various times subsequent to the onset of coma; b) evaluating phase synchronization patterns between electroencephalogram signals obtained at two different times; d) calculating the temporal variability of the synchronized patterns, wherein increased variability in the electroencephalogram signal over time is indicative of an improvement in the patient. - View Dependent Claims (18)
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Specification