System and device for maintaining physiological levels of steroid hormone in a subject

• US 20100022991A1
• Filed: 07/24/2008
• Published: 01/28/2010
• Est. Priority Date: 07/24/2008
• Status: Abandoned Application

• Current Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Wood, Lowell L. JR., Rivet, Dennis J., Hyde, Roderick A., Sweeney, Elizabeth A., Wood, Victoria Y.H.
• Application Number:
  US12/220,707
• Publication Number:
  US 20100022991A1
• Time in Patent Office: Days
• US Class Current: 604/891.100
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: A61P 5/24 of the sex hormones
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients

Abstract

A system, device, or method is provided which maintains a substantially physiological level or a substantially physiological cyclic pre-menopausal level of one or more steroid hormones in a mammalian subject in need thereof. The system, device, or method includes providing to the subject at least one treatment regimen including replacement therapy for the one or more steroid hormones or metabolites or modulators thereof, wherein the at least one treatment regimen is determined based on pre-menopausal cyclic steroid hormone levels of the subject and on current cyclic steroid hormone levels of the subject, wherein the at least one treatment regimen is configured to maintain the subject'"'"'s one or more steroid hormones or metabolites or modulators thereof at substantially physiological cyclic pre-menopausal levels. The system, device, or methods can be used for the treatment of a disease or condition in the mammalian subject.

Claims

1. A system comprising:

a signal-bearing medium including,

one or more instructions for determining at least one treatment regimen including replacement therapy for one or more steroid hormones or metabolites or modulators thereof in a subject, based on pre-menopausal cyclic steroid hormone levels of the subject and on current cyclic steroid hormone levels in the subject.

2. The system of claim 1, further comprising one or more instructions for inputting information associated with the pre-menopausal cyclic steroid hormone levels in the subject;

and one or more instructions for inputting information associated with the current cyclic steroid hormone levels in the subject.

3. The system of claim 1, wherein the at least one treatment regimen is configured to maintain a substantially physiological cyclic pre-menopausal level of one or more steroid hormones in the subject in need thereof.

4. The system of claim 1, wherein the signal bearing medium includes a computer readable medium.

5. The system of claim 1, wherein the signal bearing medium includes a recordable medium.

6. The system of claim 1, wherein the signal bearing medium includes a communications medium.

7. The system of claim 1, further comprising one or more instructions for determining the one or more steroid hormones levels in the subject during a treatment period.

8. The system of claim 1, further comprising one or more instructions for determining at least one second treatment regimen adjusted to maintain the subject'"'"'s one or more steroid hormones or one or more metabolites or modulators thereof, at substantially physiological cyclic pre-menopausal levels of the subject.

9. A system comprising:

circuitry for determining at least one treatment regimen including replacement therapy for one or more steroid hormones or metabolites or modulators thereof in a subject, based on pre-menopausal cyclic steroid hormone levels of the subject and on current cyclic steroid hormone levels in the subject.

10. The system of claim 9, further comprising circuitry for inputting information associated with the pre-menopausal cyclic steroid hormone levels in the subject;

and circuitry for inputting information associated with the current cyclic steroid hormone levels in the subject.

11. The system of claim 9, wherein the at least one treatment regimen is configured to maintain a substantially physiological cyclic pre-menopausal level of one or more steroid hormones in the subject in need thereof.

12. The system of claim 9, further comprising circuitry for determining the one or more steroid hormones levels in the subject during a treatment period.

13. The system of claim 9, further comprising circuitry for determining at least one second treatment regimen adjusted to maintain the subject'"'"'s one or more steroid hormones or one or more metabolites or modulators thereof, at substantially physiological cyclic pre-menopausal levels to the subject.

14. A device comprising:

a system including a signal-bearing medium including,

one or more instructions for determining at least one treatment regimen including replacement therapy for one or more steroid hormones or metabolites or modulators thereof in a subject, based on pre-menopausal cyclic steroid hormone levels of the subject and on current cyclic steroid hormone levels in the subject.

15. The device of claim 14, further comprising one or more instructions for inputting information associated with the pre-menopausal cyclic steroid hormone levels in the subject;

and one or more instructions for inputting information associated with the current cyclic steroid hormone levels in the subject.

16. The device of claim 14, wherein the treatment regimen is configured to maintain a substantially physiological cyclic pre-menopausal level of one or more steroid hormones in the subject in need thereof.

17. The device of claim 14, further comprising one or more polymer patches or dosing implants for varied release of the at least one treatment regimen.

18. The device of claim 17, further comprising a sensor configured to detect the subject'"'"'s pre-menopausal cyclic steroid hormone level or current cyclic steroid hormone level, the device configured to transmit a signal to the one or more polymer patches or dosing implants.

19. The device of claim 14, wherein the signal bearing medium includes a computer readable medium.

20. The device of claim 14, wherein the signal bearing medium includes a recordable medium.

21. The device of claim 14, wherein the signal bearing medium includes a communications medium.

22. The device of claim 14, further comprising one or more instructions for determining the one or more steroid hormones levels in the subject during a treatment period.

23. The device of claim 14, further comprising one or more instructions for determining at least one second treatment regimen adjusted to maintain the subject'"'"'s one or more steroid hormones or one or more metabolites or modulators thereof at substantially physiological cyclic pre-menopausal levels of the subject.

24-42. -42. (canceled)

43. A device programmed to maintain physiological cyclic levels of one or more steroid hormones in a mammalian subject by a method for restoring a physiological level of one or more steroid hormones in a mammalian subject including providing to the subject at least one treatment regimen including replacement therapy for the one or more steroid hormones or metabolites or modulators thereof, wherein the at least one treatment regimen is determined based on the subject'"'"'s pre-menopausal cyclic steroid hormone levels and on current cyclic steroid hormone levels in the subject, wherein the at least one treatment regimen is configured to maintain the subject'"'"'s one or more steroid hormones or metabolites or modulators thereof at substantially physiological cyclic pre-menopausal levels.

44. The device of claim 43, further comprising one or more instructions for inputting information associated with the pre-menopausal cyclic steroid hormone levels of the subject;

and one or more instructions for inputting information associated with the current cyclic steroid hormone levels of the subject.

45. The device of claim 43, further comprising one or more polymer patches or dosing implants for varied release of the dosing formulation.

46. The device of claim 44, further comprising one or more computerized dosing implants responsive to sensored changes in the subject'"'"'s pre-menopausal cyclic steroid hormone levels and the subject'"'"'s peri-menopausal or post-menopausal steroid hormone levels.