BIOCORRODIBLE IMPLANT WITH A COATING COMPRISING A HYDROGEL

• US 20100023112A1
• Filed: 07/22/2009
• Published: 01/28/2010
• Est. Priority Date: 07/28/2008
• Status: Abandoned Application

• Current Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Original Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Inventors: Borck, Alexander, Adden, Nina
• Application Number:
  US12/507,216
• Publication Number:
  US 20100023112A1
• Time in Patent Office: Days
• US Class Current: 623/1.150
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body

Abstract

The invention relates to an implant having a base body consisting completely or partially of a biocorrodible metallic material, the material being such that it decomposes in an aqueous environment to yield an alkaline product and the base body has a coating comprising or containing a hydrogel, characterized in that the hydrogel has a reduced swelling capacity at an elevated pH.

Claims

1. An implant with a base body comprising completely or partially a biocorrodible metallic material, where the material has properties such that it decomposes to form an alkaline product in an aqueous environment, and where the base body has a coating comprising or containing a hydrogel, characterized in that the hydrogel has a reduced swelling capacity at an elevated pH.

2. The implant according to claim 1, wherein the implant is a stent.

3. The implant according to claim 1, wherein the biocorrodible metallic material is a magnesium alloy.

4. The implant according to claim 1, wherein the swelling capacity of the hydrogel is reduced at a pH greater than 8.

5. The implant according to claim 1, wherein the swelling capacity of the hydrogel is reduced at a pH greater than 8, such that the hydrogel can absorb at least 30% less water than at a physiological pH.

6. The implant according to claim 1, wherein the hydrogel has at least one functional group which is converted from an ionic charge state to a neutral charge state with an increase in pH.

7. The implant according to claim 6, wherein the functional group is selected from the group comprising an amine function and an amide function.

8. The implant according to claim 1, wherein the hydrogel comprises a polymer selected from the group consisting of acrylamide, methacrylamide, dimethylaminoethyl methacrylate, a derivative of an acrylamide, methacrylamide and dimethyl-aminoethyl methacrylate.

9. The implant according to claim 1, wherein the implant has another outer coating comprising a degradable polymer, PLGA (poly(lactic-co-glycolic acid)) or PLGA-PEG block copolymers.

10. The implant according to claim 1, wherein the coating comprises at least one drug.