CHARGED PARTICLE CANCER THERAPY AND PATIENT POSITIONING METHOD AND APPARATUS

• US 20100027745A1
• Filed: 09/06/2009
• Published: 02/04/2010
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Granted Patent: US 8,378,321 B2
• Time in Patent Office: Days
• US Class Current: 378/65
• CPC Class Codes: A61B 6/04 Positioning of patients; Tiltable beds or the like operating tables A61G13/00; operating chairs A61G15/00
• CPC Class Codes: A61B 6/4028 resulting in acquisition of views from substantially different positions, e.g. EBCT
• CPC Class Codes: A61B 6/4092 for producing synchrotron radiation
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/08 Arrangements for injecting particles into orbits
• CPC Class Codes: H05H 7/12 Arrangements for varying final energy of beam

Abstract

The invention comprises a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Claims

1. An apparatus for irradiating a tumor in a patient with charged particles extracted from a synchrotron, said apparatus configured to restrict movement of at least one arm or leg of the patient out of a charged particle path of the synchrotron, said apparatus comprising:

a charged particle irradiation system comprising;

an exit nozzle;

a first about horizontal charged particle beam path from said exit nozzle to a rotationally variable incident portion of the patient; and

a second about horizontal charged particle beam path from the rotationally variable incident portion of the patient to the tumor;

a rotatable platform configured to semi-constrain the patient in a laying position, wherein said rotatable platform rotates about an axis aligned with gravity;

a semi-restraint system configured to hold at least one of the arm and the leg of the patient out of the first about horizontal charged particle beam path from said exit nozzle to the patient,

wherein said charged particle irradiation system delivers the charged particle in at least five rotation positions of said rotatable platform.

2. The apparatus of claim 1, wherein the charged particles flow in said second charged particle beam path above a portion of said rotatable platform to the tumor.

3. The apparatus of claim 1, wherein said rotatable platform comprises a motorized vertical axis adjustment vertically configuring the tumor of the patient to overlap said about second about horizontal charged particle beam path.

4. The apparatus of claim 1, further comprising:

an X-ray beam path substantially overlapping said second about horizontal charged particle beam path, wherein an X-ray source generating X-rays running along said X-ray beam path maintains a single static position;

(1) during use of said X-ray source; and

(2) during tumor treatment with said charged particle irradiation system.

5. The apparatus of claim 1, said charged particle irradiation system further comprising:

a scanning system configured to direct in three-dimensions the charged particles to a spot focal point in the tumor, said scanning system focusing the charged particles from the nozzle to the tumor.

6. The apparatus of claim 1, wherein said charged particle beam path runs through said synchrotron, wherein said charged particle irradiation system further comprises:

an extraction material;

at least a one kilovolt direct current field applied across a pair of extraction blades; and

a deflector,

wherein charged particles circulating in said synchrotron transport through said extraction material resulting in reduced energy charged particles,

wherein the reduced energy charged particles pass between said pair of extraction blades, and

wherein the direct current field redirects the reduced energy charged particles through said deflector,

wherein said deflector yields the charged particles extracted from said synchrotron, said charged particles exiting through said nozzle.

7. The apparatus of claim 6, wherein said rotatable platform comprises an attachment surface, wherein wheels attached to said rotatable platform allow movement of the patient on said platform from a preparation room to a radiation treatment room.

8. The apparatus of claim 1, said synchrotron further comprising:

a center; and

a charged particle circulation beam path running;

about said center;

through straight sections; and

through turning sections,

wherein each of said turning sections comprise at least four bending magnets, said four bending magnets comprising at least eight edge focusing surfaces,

wherein said circulation beam path comprises a length of less than sixty meters, and

wherein a number of said straight sections equals a number of said turning sections.

9. The apparatus of claim 1, said synchrotron further comprising:

a center; and

a charged particle circulation beam path running;

about said center;

through straight sections; and

through turning sections,

wherein each of said turning sections comprises a plurality of bending magnets,

wherein at least two of said plurality of bending magnets further comprise a magnetic field focusing section, said focusing section comprising;

a geometry tapering from a first cross-sectional area to a second cross-sectional area, said second cross-sectional area comprising less than two-thirds of an area of said first cross-sectional area, said second cross-sectional area planar to and proximate said charged particle beam path.

10. A method for irradiating a tumor in a patient with charged particles extracted from a synchrotron, said apparatus configured to restrict movement of at least one arm or leg of the patient out of a charged particle path of the synchrotron, said method comprising the steps of:

delivering the charged particles with a charged particle irradiation system;

first from an exit nozzle along a first about horizontal charged particle beam path to a rotationally variable incident portion of the patient; and

second from the rotationally variable incident portion of the patient along a second about horizontal charged particle beam path to the tumor;

semi-constraining the patient in a laying position on a rotatable platform, wherein said rotatable platform rotates about an axis aligned with gravity;

restraining at least one of the arm and the leg of the patient out of the first about horizontal charged particle beam path from said exit nozzle to the patient,

irradiating the tumor with the charged particles in at least five rotation positions of said rotatable platform during a single tumor treatment session.

11. The method of claim 10, further comprising the steps of:

using positioning constraints to initially positioning the patient to a position, said positioning constraints using computer controlled motorized components;

recording positions of said motorized components;

locating the tumor in the patient using medical devices;

allowing the patient to exit from said position; and

repositioning the patient using said recorded positions of said computer controlled motorized components.

12. The method of claim 11 further comprising the step of:

developing a tumor irradiation plan after said step of recording and prior to said step of repositioning.

13. The method of claim 10, further comprising the steps of:

focusing the charged particles to a delivery volume, wherein said volume comprises a largest horizontal or vertical cross-section distance of less than about two millimeters; and

scanning said volume in three dimensional space inside the tumor.

14. The method of claim 10, further comprising the step of:

inversely varying intensity of the charged particles versus a distance from said rotationally variable incident portion of the patient to a distal portion of the tumor.

15. The method of claim 10, further comprising the steps of:

controlling timing of injection of the charged particles into said synchrotron;

controlling timing of acceleration of the charged particles in said synchrotron;

controlling timing of extraction of the charged particles from said synchrotron, wherein all of;

said step of controlling timing of said injection, said step of controlling timing of acceleration, and said step of controlling timing of extraction correlate with each of at least five successive respirations of the patient.

16. A method for irradiating a tumor of a patient with charged particles running along a charged particle beam path, said method comprising the steps of:

semi-constraining the patient in a laying position on a rotatable platform, wherein said rotatable platform rotates to at least five rotation positions;

restraining at least one of the arm and the leg of the patient out of the charged particle beam path,

irradiating the tumor with the charged particles in each of said at least five rotation positions during a single tumor treatment session.

17. The method of claim 16, further comprising the steps of:

accelerating the charged particles with a synchrotron;

monitoring a breathing cycle of the patient with a respiration sensor, said respiration sensor generating a respiration signal corresponding to the breathing cycle;

rotating said platform through at least one hundred eighty degrees during an irradiation period of the patient,

using the respiration signal, delivering the charged particles to the tumor at a set point in the breathing cycle.

18. The method of claim 16, further comprising the steps of:

generating X-rays with an X-ray generation source, said X-ray generation source comprising;

an electron generating cathode;

a control electrode;

a plurality of accelerating electrodes;

a magnetic lens; and

a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and an anode, said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet combining to form a substantially parallel electron beam with an electron beam cross-sectional area, wherein a cross-sectional area of said cathode is greater than about six times that of the electron beam cross-sectional area,

wherein the X-rays generated by the electrons from said cathode strike said tungsten anode, and

wherein the X-rays emitted from said anode substantially overlap the charged particle beam path in the patient.

19. The method of claim 16, further comprising the steps of:

accelerating the charged particle beam with a synchrotron;

focusing the charged particles with a focal system to a volume of less than about two millimeters in vertical diameter;

controlling kinetic energy of the charged particles using at least one correction coil in said synchrotron; and

actively scanning the charged particles at the tumor with an active scanning system, wherein said active scanning system simultaneously scans the charged particles along all of;

a horizontal axis;

a vertical axis; and

a kinetic energy axis.

20. The method of claim 19, further comprising the steps of:

transmitting the circulating charged particle beam through an extraction material in said synchrotron, said extraction material yielding both;

a reduced energy charged particle beam; and

a secondary emission current;

applying a field of at least five hundred volts across a pair of extraction blades;

passing the reduced energy charged particle beam between said pair of extraction blades,

wherein said field redirects the reduced energy charged particle as an extracted charged particle beam, and

wherein said step of irradiating irradiates the tumor with the charged particle beam.