System and Method for Pseudo-Continuous Measurement of Metabolite Concentrations in a Mammalian Body
First Claim
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1. A metabolite monitoring system comprising:
- (a) a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet;
(b) a fluid delivery device for delivering dialysate to said inlet; and
(c) a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.
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Abstract
A metabolite monitoring system comprising a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet, a fluid delivery device for delivering dialysate to said inlet; and a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.
51 Citations
19 Claims
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1. A metabolite monitoring system comprising:
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(a) a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet; (b) a fluid delivery device for delivering dialysate to said inlet; and (c) a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A metabolite monitoring system comprising:
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(a) a microdialysis probe; (b) a dialysate delivery arrangement for generating flow of a dialysate into and out from said microdialysis probe; and (c) a reagent delivery arrangement for supplying a reagent for mixing with the dialysate from said microdialysis probe, wherein said reagent delivery arrangement and said dialysate delivery arrangement each includes a fluid reservoir acted upon by a piston to deliver the fluid, wherein said reagent delivery arrangement and said dialysate delivery arrangement are mechanically linked so as to maintain a fixed ratio between a quantity of dialysate delivered and a quantity of reagent delivered. - View Dependent Claims (16, 17, 18)
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19-26. -26. (canceled)
Specification