Preparation method for biodegradable micro-particles containing drugs
First Claim
1. A method of preparing drug-containing microparticles comprising:
- dissolving a biodegradable polymer in organic solvent to form a polymer solution;
dissolving or dispersing a drug in the polymer solution to form a polymer-drug-solvent phase;
mixing the polymer-drug-solvent phase with an aqueous suspension comprising an inorganic gel to form a dispersion comprising polymer-drug droplets dispersed in the aqueous suspension, wherein the inorganic gel can be dissolved by acid;
evaporating the organic solvent from the dispersion to convert the polymer-drug droplets to drug-containing microparticles; and
recovering the drug-containing microparticles from the dispersion, wherein the step of recovering the drug-containing microparticles from the dispersion comprises adding acid to the dispersion to dissolve the inorganic gel.
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Abstract
The disclosure provides a method to form sustained release drug-containing microparticles with a biodegradable polymer. The method involves forming a polymer-drug-organic solvent phase, and dispersing the polymer-drug-organic solvent phase in an aqueous suspension of an inorganic gel, which may be hydroxyapatite. The hydroxyapatite appears to coat the polymer-drug-solvent droplets to prevent them coalescing. The solvent then evaporates with stirring of the dispersion, at which time the droplets solidify to drug-containing microparticles. The inorganic gel allows suitably small microparticles to form without use of an organic emulsifier.
5 Citations
19 Claims
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1. A method of preparing drug-containing microparticles comprising:
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dissolving a biodegradable polymer in organic solvent to form a polymer solution; dissolving or dispersing a drug in the polymer solution to form a polymer-drug-solvent phase; mixing the polymer-drug-solvent phase with an aqueous suspension comprising an inorganic gel to form a dispersion comprising polymer-drug droplets dispersed in the aqueous suspension, wherein the inorganic gel can be dissolved by acid; evaporating the organic solvent from the dispersion to convert the polymer-drug droplets to drug-containing microparticles; and recovering the drug-containing microparticles from the dispersion, wherein the step of recovering the drug-containing microparticles from the dispersion comprises adding acid to the dispersion to dissolve the inorganic gel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification