METHOD FOR IMPROVING HEAT STABILITY OF COMPOSITION CONTAINING WATER-SOLUBLE COENZYME-BOUND GLUCOSE DEHYDROGENASE (GDH)
First Claim
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1. A method for preparing a glucose sensor with soluble flavin-bound glucose dehydrogenase, which method comprises (a) providing a composition comprising soluble flavin-bound glucose dehydrogenase at a pH in the range of 3.14 to 6.97 and (b) heat drying the composition onto a surface of a glucose sensor.
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Abstract
The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH). The invention provides a method for preparing a glucose sensor with soluble flavin-bound GDH by providing a composition comprising soluble flavin-bound GDH at an acidic pH and heat drying the composition onto a glucose sensor.
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8 Claims
- 1. A method for preparing a glucose sensor with soluble flavin-bound glucose dehydrogenase, which method comprises (a) providing a composition comprising soluble flavin-bound glucose dehydrogenase at a pH in the range of 3.14 to 6.97 and (b) heat drying the composition onto a surface of a glucose sensor.
- 6. A method for preparing a glucose sensor with soluble flavin-bound glucose dehydrogenase, which method comprises (a) providing a composition comprising soluble flavin-bound glucose dehydrogenase at a pH in the range of 4.20 to 6.60 and (b) heat drying the composition onto a surface of a glucose sensor.
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