CARDIOVASCULAR COMPOSITIONS AND USE OF THE SAME FOR THE TREATMENT OF ALZHEIMER'S DISEASE
First Claim
Patent Images
1. A method of reducing Aβ
- 1-40 generation in primary cortico-hippocampal neurons of a mammal comprising administering to said mammal a composition comprising an cardiovascular agent selected from the group consisting of Metergoline;
Suloctidil;
Bumetanide;
Ethacrynic Acid;
Tetrandrine;
Perhexiline Maleate;
Amlodipine Besylate;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Fendiline Hydrochloride;
Candesartan Cilextil;
Nicardipine Hydrochloride;
Fenofibrate;
Amiodarone Hydrochloride;
Papaverine Hydrochloride;
N,N-Hexamethyleneamiloride;
Reserpine;
Simvastatin;
Cadmium Acetate;
Nitrendipine;
Propafenone Hydrochloride;
Carvedilol;
Flunarizine Hydrochloride;
Oxidopamine Hydrochloride;
Lanatoside C;
Lanatoside C;
Dicumarol;
Valsartan;
Propranolol Hydrochloride (−
);
Veratrine Sulfate;
Vinpocetine;
Spironolactone;
Protoveratrine B;
Quinidine Gluconate;
Propranolol Hydrochloride (±
);
Atorvastatin Calcium;
Hydralazine Hydrochloride;
Yohimbine Hydrochloride;
Xylometazoline Hydrochloride;
Digitoxin;
Nylidrin Hydrochloride;
Verapamil;
Cyclothiazide;
Chrysin;
Scopoletin;
Dipyridamole;
Nifedipine;
Althiazide;
Losartan;
Nicergoline;
Bendrofumethiazide;
Probucol;
Amiloride Hydrochloride;
Oxymetazoline Hydrochloride;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride;
Pargyline Hydrochloride;
Nimodipine;
Neriifolin;
Nicotinyl Tartrate;
Isosorbide Dinitrate;
Pempidine Tartrate;
2-(2,6-Dimethoxyphenoxyethyl);
Aminomethyl-1,4-Benzodioxane;
Hydrochloride;
Phentolamine Hydrochloride;
Disopyramide Phosphate;
Rosuvastatin;
Perindopril Erbumine;
Olmesartan Medoxomil;
Hexamethonium Bromide;
Labetalol Hydrochloride;
Tranexamic Acid; and
Dopamine Hydrochloride;
analogs thereof and combinations thereof.
1 Assignment
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Accused Products
Abstract
Methods and compositions for the treatment of Alzheimer'"'"'s Disease are described. More specifically, the invention demonstrates that administration of cardiovascular agents to a mammal suffering from the symptoms of Alzheimer'"'"'s Disease causes an amelioration of those symptoms. The finding of the present invention can be used in treatment regimens designed to attenuate or prevent Alzheimer'"'"'s Disease.
21 Citations
24 Claims
-
1. A method of reducing Aβ
- 1-40 generation in primary cortico-hippocampal neurons of a mammal comprising administering to said mammal a composition comprising an cardiovascular agent selected from the group consisting of Metergoline;
Suloctidil;
Bumetanide;
Ethacrynic Acid;
Tetrandrine;
Perhexiline Maleate;
Amlodipine Besylate;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Fendiline Hydrochloride;
Candesartan Cilextil;
Nicardipine Hydrochloride;
Fenofibrate;
Amiodarone Hydrochloride;
Papaverine Hydrochloride;
N,N-Hexamethyleneamiloride;
Reserpine;
Simvastatin;
Cadmium Acetate;
Nitrendipine;
Propafenone Hydrochloride;
Carvedilol;
Flunarizine Hydrochloride;
Oxidopamine Hydrochloride;
Lanatoside C;
Lanatoside C;
Dicumarol;
Valsartan;
Propranolol Hydrochloride (−
);
Veratrine Sulfate;
Vinpocetine;
Spironolactone;
Protoveratrine B;
Quinidine Gluconate;
Propranolol Hydrochloride (±
);
Atorvastatin Calcium;
Hydralazine Hydrochloride;
Yohimbine Hydrochloride;
Xylometazoline Hydrochloride;
Digitoxin;
Nylidrin Hydrochloride;
Verapamil;
Cyclothiazide;
Chrysin;
Scopoletin;
Dipyridamole;
Nifedipine;
Althiazide;
Losartan;
Nicergoline;
Bendrofumethiazide;
Probucol;
Amiloride Hydrochloride;
Oxymetazoline Hydrochloride;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride;
Pargyline Hydrochloride;
Nimodipine;
Neriifolin;
Nicotinyl Tartrate;
Isosorbide Dinitrate;
Pempidine Tartrate;
2-(2,6-Dimethoxyphenoxyethyl);
Aminomethyl-1,4-Benzodioxane;
Hydrochloride;
Phentolamine Hydrochloride;
Disopyramide Phosphate;
Rosuvastatin;
Perindopril Erbumine;
Olmesartan Medoxomil;
Hexamethonium Bromide;
Labetalol Hydrochloride;
Tranexamic Acid; and
Dopamine Hydrochloride;
analogs thereof and combinations thereof. - View Dependent Claims (9, 10, 11, 12)
- 1-40 generation in primary cortico-hippocampal neurons of a mammal comprising administering to said mammal a composition comprising an cardiovascular agent selected from the group consisting of Metergoline;
-
2. A method of reducing Aβ
- 1-42 generation in primary cortico-hippocampal neurons of a mammal comprising administering to said mammal a composition comprising an cardiovascular agent selected from the group consisting of Ethacrynic Acid;
Metergoline;
Cadmium Acetate;
Suloctidil;
Amlodipine Besylate;
Candesartan Cilextil;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Amiodarone Hydrochloride;
Tetrandrine;
Perhexiline Maleate;
Fendiline Hydrochloride;
N,N-Hexamethyleneamiloride;
Nicardipine Hydrochloride;
Papaverine Hydrochloride;
Carvedilol;
Propranolol Hydrochloride (−
);
Oxidopamine Hydrochloride;
Reserpine;
Valsartan;
Oxymetazoline Hydrochloride;
Pindolol;
Amiloride Hydrochloride;
Flunarizine Hydrochloride;
Tranexamic Acid;
Dicumarol;
Propafenone Hydrochloride;
Bendrofumethiazide;
Dipyridamole;
Hydralazine Hydrochloride;
Nitrendipine;
Triamterene;
Althiazide;
Rosuvastatin;
Disopyramide Phosphate;
Isosorbide Dinitrate;
Alfluzosin;
Yohimbine Hydrochloride;
Bucladesine;
Quinidine Gluconate;
Spironolactone;
Olmesartan Medoxomil;
Xylometazoline Hydrochloride;
Hexamethonium Bromide;
Phentolamine Hydrochloride;
Nicotinyl Tartrate;
Rauwolscine Hydrochloride;
Bumetanide;
Cyclothiazide;
Midodrine Hydrochloride;
Atorvastatin Calcium;
Fenofibrate;
Dopamine Hydrochloride;
Pempidine Tartrate;
Fenoterol Hydrobromide;
Irbesartan;
Chrysin;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride; and
Trichlormethiazide and analogs thereof and combinations thereof.
- 1-42 generation in primary cortico-hippocampal neurons of a mammal comprising administering to said mammal a composition comprising an cardiovascular agent selected from the group consisting of Ethacrynic Acid;
-
3. A method of treating Alzheimer'"'"'s disease in a mammal comprising administering to said mammal a composition comprising an cardiovascular agent agent selected from the group consisting of Metergoline;
- Suloctidil;
Bumetanide;
Ethacrynic Acid;
Tetrandrine;
Perhexiline Maleate;
Amlodipine Besylate;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Fendiline Hydrochloride;
Candesartan Cilextil;
Nicardipine Hydrochloride;
Fenofibrate;
Amiodarone Hydrochloride;
Papaverine Hydrochloride;
N,N-Hexamethyleneamiloride;
Reserpine;
Simvastatin;
Cadmium Acetate;
Nitrendipine;
Propafenone Hydrochloride;
Carvedilol;
Flunarizine Hydrochloride;
Oxidopamine Hydrochloride;
Lanatoside C;
Lanatoside C;
Dicumarol;
Valsartan;
Propranolol Hydrochloride (−
);
Veratrine Sulfate;
Vinpocetine;
Spironolactone;
Protoveratrine B;
Quinidine Gluconate;
Propranolol Hydrochloride (±
);
Atorvastatin Calcium;
Hydralazine Hydrochloride;
Yohimbine Hydrochloride;
Xylometazoline Hydrochloride;
Digitoxin;
Nylidrin Hydrochloride;
Verapamil;
Cyclothiazide;
Chrysin;
Scopoletin;
Dipyridamole;
Nifedipine;
Althiazide;
Losartan;
Nicergoline;
Bendrofumethiazide;
Probucol;
Amiloride Hydrochloride;
Oxymetazoline Hydrochloride;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride;
Pargyline Hydrochloride;
Nimodipine;
Neriifolin;
Nicotinyl Tartrate;
Isosorbide Dinitrate;
Pempidine Tartrate;
2-(2,6-Dimethoxyphenoxyethyl);
Aminomethyl-1,4-Benzodioxane;
Hydrochloride;
Phentolamine Hydrochloride;
Disopyramide Phosphate;
Rosuvastatin;
Perindopril Erbumine;
Olmesartan Medoxomil;
Hexamethonium Bromide;
Labetalol Hydrochloride;
Tranexamic Acid; and
Dopamine Hydrochloride;
analogs thereof and combinations thereof, in an amount effective to ameliorate at least one symptom of said disease in said mammal. - View Dependent Claims (5, 6, 7, 8)
- Suloctidil;
-
4. A method of treating Alzheimer'"'"'s disease in a mammal comprising administering to said mammal a composition comprising an cardiovascular agent agent selected from the group consisting of Ethacrynic Acid;
- Metergoline;
Cadmium Acetate;
Suloctidil;
Amlodipine Besylate;
Candesartan Cilextil;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Amiodarone Hydrochloride;
Tetrandrine;
Perhexiline Maleate;
Fendiline Hydrochloride;
N,N-Hexamethyleneamiloride;
Nicardipine Hydrochloride;
Papaverine Hydrochloride;
Carvedilol;
Propranolol Hydrochloride (−
);
Oxidopamine Hydrochloride;
Reserpine;
Valsartan;
Oxymetazoline Hydrochloride;
Pindolol;
Amiloride Hydrochloride;
Flunarizine Hydrochloride;
Tranexamic Acid;
Dicumarol;
Propafenone Hydrochloride;
Bendrofumethiazide;
Dipyridamole;
Hydralazine Hydrochloride;
Nitrendipine;
Triamterene;
Althiazide;
Rosuvastatin;
Disopyramide Phosphate;
Isosorbide Dinitrate;
Alfluzosin;
Yohimbine Hydrochloride;
Bucladesine;
Quinidine Gluconate;
Spironolactone;
Olmesartan Medoxomil;
Xylometazoline Hydrochloride;
Hexamethonium Bromide;
Phentolamine Hydrochloride;
Nicotinyl Tartrate;
Rauwolscine Hydrochloride;
Bumetanide;
Cyclothiazide;
Midodrine Hydrochloride;
Atorvastatin Calcium;
Fenofibrate;
Dopamine Hydrochloride;
Pempidine Tartrate;
Fenoterol Hydrobromide;
Irbesartan;
Chrysin;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride; and
Trichlormethiazide and analogs thereof and combinations thereof.
- Metergoline;
-
13. Use of an cardiovascular agent selected from the group consisting of Ethacrynic Acid;
- Metergoline;
Cadmium Acetate;
Suloctidil;
Amlodipine Besylate;
Candesartan Cilextil;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Amiodarone Hydrochloride;
Tetrandrine;
Perhexiline Maleate;
Fendiline Hydrochloride;
N,N-Hexamethyleneamiloride;
Nicardipine Hydrochloride;
Papaverine Hydrochloride;
Carvedilol;
Propranolol Hydrochloride (−
);
Oxidopamine Hydrochloride;
Reserpine;
Valsartan;
Oxymetazoline Hydrochloride;
Pindolol;
Amiloride Hydrochloride;
Flunarizine Hydrochloride;
Tranexamic Acid;
Dicumarol;
Propafenone Hydrochloride;
Bendrofumethiazide;
Dipyridamole;
Hydralazine Hydrochloride;
Nitrendipine;
Triamterene;
Althiazide;
Rosuvastatin;
Disopyramide Phosphate;
Isosorbide Dinitrate;
Alfluzosin;
Yohimbine Hydrochloride;
Bucladesine;
Quinidine Gluconate;
Spironolactone;
Olmesartan Medoxomil;
Xylometazoline Hydrochloride;
Hexamethonium Bromide;
Phentolamine Hydrochloride;
Nicotinyl Tartrate;
Rauwolscine Hydrochloride;
Bumetanide;
Cyclothiazide;
Midodrine Hydrochloride;
Atorvastatin Calcium;
Fenofibrate;
Dopamine Hydrochloride;
Pempidine Tartrate;
Fenoterol Hydrobromide;
Irbesartan;
Chrysin;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride; and
Trichlormethiazide and analogs and combinations thereof for the manufacture of a medicament for the treatment of Alzheimer'"'"'s Disease. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
- Metergoline;
-
14. Use of an cardiovascular agent selected from the group consisting of Ethacrynic Acid;
- Metergoline;
Cadmium Acetate;
Suloctidil;
Amlodipine Besylate;
Candesartan Cilextil;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Amiodarone Hydrochloride;
Tetrandrine;
Perhexiline Maleate;
Fendiline Hydrochloride;
N,N-Hexamethyleneamiloride;
Nicardipine Hydrochloride;
Papaverine Hydrochloride;
Carvedilol;
Propranolol Hydrochloride (−
);
Oxidopamine Hydrochloride;
Reserpine;
Valsartan;
Oxymetazoline Hydrochloride;
Pindolol;
Amiloride Hydrochloride;
Flunarizine Hydrochloride;
Tranexamic Acid;
Dicumarol;
Propafenone Hydrochloride;
Bendrofumethiazide;
Dipyridamole;
Hydralazine Hydrochloride;
Nitrendipine;
Triamterene;
Althiazide;
Rosuvastatin;
Disopyramide Phosphate;
Isosorbide Dinitrate;
Alfluzosin;
Yohimbine Hydrochloride;
Bucladesine;
Quinidine Gluconate;
Spironolactone;
Olmesartan Medoxomil;
Xylometazoline Hydrochloride;
Hexamethonium Bromide;
Phentolamine Hydrochloride;
Nicotinyl Tartrate;
Rauwolscine Hydrochloride;
Bumetanide;
Cyclothiazide;
Midodrine Hydrochloride;
Atorvastatin Calcium;
Fenofibrate;
Dopamine Hydrochloride;
Pempidine Tartrate;
Fenoterol Hydrobromide;
Irbesartan;
Chrysin;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride; and
Trichlormethiazide and analogs and combinations for the treatment of Alzheimer'"'"'s Disease.
- Metergoline;
-
15. Use of an cardiovascular agent selected from the group consisting of Metergoline;
- Suloctidil;
Bumetanide;
Ethacrynic Acid;
Tetrandrine;
Perhexiline Maleate;
Amlodipine Besylate;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Fendiline Hydrochloride;
Candesartan Cilextil;
Nicardipine Hydrochloride;
Fenofibrate;
Amiodarone Hydrochloride;
Papaverine Hydrochloride;
N,N-Hexamethyleneamiloride;
Reserpine;
Simvastatin;
Cadmium Acetate;
Nitrendipine;
Propafenone Hydrochloride;
Carvedilol;
Flunarizine Hydrochloride;
Oxidopamine Hydrochloride;
Lanatoside C;
Lanatoside C;
Dicumarol;
Valsartan;
Propranolol Hydrochloride (−
);
Veratrine Sulfate;
Vinpocetine;
Spironolactone;
Protoveratrine B;
Quinidine Gluconate;
Propranolol Hydrochloride (±
);
Atorvastatin Calcium;
Hydralazine Hydrochloride;
Yohimbine Hydrochloride;
Xylometazoline Hydrochloride;
Digitoxin;
Nylidrin Hydrochloride;
Verapamil;
Cyclothiazide;
Chrysin;
Scopoletin;
Dipyridamole;
Nifedipine;
Althiazide;
Losartan;
Nicergoline;
Bendrofumethiazide;
Probucol;
Amiloride Hydrochloride;
Oxymetazoline Hydrochloride;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride;
Pargyline Hydrochloride;
Nimodipine;
Neriifolin;
Nicotinyl Tartrate;
Isosorbide Dinitrate;
Pempidine Tartrate;
2-(2,6-Dimethoxyphenoxyethyl);
Aminomethyl-1,4-Benzodioxane;
Hydrochloride;
Phentolamine Hydrochloride;
Disopyramide Phosphate;
Rosuvastatin;
Perindopril Erbumine;
Olmesartan Medoxomil;
Hexamethonium Bromide;
Labetalol Hydrochloride;
Tranexamic Acid; and
Dopamine Hydrochloride;
analogs thereof and combinations thereof for the manufacture of a medicament for the treatment of Alzheimer'"'"'s Disease.
- Suloctidil;
-
16. Use of an cardiovascular agent selected from the group consisting of Metergoline;
- Suloctidil;
Bumetanide;
Ethacrynic Acid;
Tetrandrine;
Perhexiline Maleate;
Amlodipine Besylate;
Bepridil Hydrochloride;
Prazosin Hydrochloride;
Fendiline Hydrochloride;
Candesartan Cilextil;
Nicardipine Hydrochloride;
Fenofibrate;
Amiodarone Hydrochloride;
Papaverine Hydrochloride;
N,N-Hexamethyleneamiloride;
Reserpine;
Simvastatin;
Cadmium Acetate;
Nitrendipine;
Propafenone Hydrochloride;
Carvedilol;
Flunarizine Hydrochloride;
Oxidopamine Hydrochloride;
Lanatoside C;
Lanatoside C;
Dicumarol;
Valsartan;
Propranolol Hydrochloride (−
);
Veratrine Sulfate;
Vinpocetine;
Spironolactone;
Protoveratrine B;
Quinidine Gluconate;
Propranolol Hydrochloride (±
);
Atorvastatin Calcium;
Hydralazine Hydrochloride;
Yohimbine Hydrochloride;
Xylometazoline Hydrochloride;
Digitoxin;
Nylidrin Hydrochloride;
Verapamil;
Cyclothiazide;
Chrysin;
Scopoletin;
Dipyridamole;
Nifedipine;
Althiazide;
Losartan;
Nicergoline;
Bendrofumethiazide;
Probucol;
Amiloride Hydrochloride;
Oxymetazoline Hydrochloride;
Isoxsuprine Hydrochloride;
Isoxsuprine Hydrochloride;
Pargyline Hydrochloride;
Nimodipine;
Neriifolin;
Nicotinyl Tartrate;
Isosorbide Dinitrate;
Pempidine Tartrate;
2-(2,6-Dimethoxyphenoxyethyl);
Aminomethyl-1,4-Benzodioxane;
Hydrochloride;
Phentolamine Hydrochloride;
Disopyramide Phosphate;
Rosuvastatin;
Perindopril Erbumine;
Olmesartan Medoxomil;
Hexamethonium Bromide;
Labetalol Hydrochloride;
Tranexamic Acid; and
Dopamine Hydrochloride;
analogs thereof and combinations thereof for the treatment of Alzheimer'"'"'s Disease.
- Suloctidil;
Specification