MODELING OF PHARMACEUTICAL PROPAGATION
First Claim
1. A method of delivering a contrast enhancing fluid to a patient using an injector system, comprising:
- determining at least one patient transfer function for the patient based upon data specific to the patient and based at least in part on a measurement of cardiac output of the patient, the at least one patient transfer function providing a time enhancement output for a given input;
determining a desired time enhancement output;
using the at least one patient transfer function to determine an injection procedure input; and
controlling the injector system at least in part on the basis of the determined injection procedure input.
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Accused Products
Abstract
A method of delivering a contrast enhancing fluid to a patient using an injector system, including: determining at least one patient transfer function for the patient based upon data specific to the patient and, the at least one patient transfer function providing a time enhancement output for a given input; determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input. The injection procedure input can determined considering at least one operational limitation or constraint of the injector system. A method of modeling propagation of a pharmaceutical fluid in a patient, includes: collecting data corresponding to a time response curve resulting from injection of the fluid; and determining at least one mathematical model describing the data. The mathematical model can, for example, be a model which is not determined by a continuous or a discrete-time Fourier deconvolution of the data. A method of controlling injection of a pharmaceutical fluid into a patient using an injector in a medical procedure, includes: collecting data corresponding to a patient response curve resulting from injection of the fluid; determining at least one mathematical model describing the data; and controlling the injector during the medical procedure to control injection of the fluid into the patient to create patient response at least in part on the basis of the mathematical model. A method of controlling injection of a contrast medium into a patient using an injector in a medical imaging procedure using an imaging scanner, includes: determining at least one mathematical model to predict a time enhancement response resulting from injection of the contrast medium; determining an injection protocol to approximate a predetermined time enhancement response in the patient by determining a constrained input solution to the mathematical model; and using the injection protocol to control the injector during the medical imaging procedure to control injection of the contrast medium into the patient to create an image of a region of interest. Patient transfer functions for the patient of the present invention can also be based at least in part on a measurement of cardiac output of the patient. Likewise, mathematical models of the present invention can be based at least in part on a measurement of cardiac output of the patient.
129 Citations
96 Claims
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1. A method of delivering a contrast enhancing fluid to a patient using an injector system, comprising:
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determining at least one patient transfer function for the patient based upon data specific to the patient and based at least in part on a measurement of cardiac output of the patient, the at least one patient transfer function providing a time enhancement output for a given input; determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40)
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35. The method of claim 35 wherein the contrast enhancing agent is iodine, xenon or gadolinium.
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41. An injector system for the delivery of a fluid to a patient comprising:
- an injector and a controller in communicative connection with the injector, the controller comprising at least one patient transfer function determined for the patient based upon data specific to the patient and at least in part on the basis of a measure cardiac output of the patient, the at least one patient transfer function providing a time enhancement output for a given input, the controller comprising a processor to determine an injection procedure input for a desired time enhancement output using the at least one patient transfer function.
- View Dependent Claims (42, 43, 44, 45, 46, 47)
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48. A method of modeling propagation of a pharmaceutical fluid in a patient, comprising:
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collecting data corresponding to a time response curve resulting from injection of the fluid; and determining at least one mathematical model describing the data and based at least in part on a measure cardiac output of the patient, provided that the mathematical model is not determined solely by a continuous or a discrete-time Fourier deconvolution of the data. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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62. A method of controlling injection of a pharmaceutical fluid into a patient using an injector in a medical procedure, comprising:
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collecting data corresponding to a patient response curve resulting from injection of the fluid; determining at least one mathematical model describing the data and based at least in part on a measured cardiac output of the patient, provided that the mathematical model is not determined solely by a continuous or a discrete-time Fourier deconvolution of the data; and controlling the injector during the medical procedure to control injection of the fluid into the patient to create patient response at least in part on the basis of the mathematical model. - View Dependent Claims (63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80)
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81. An injection system comprising:
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an injector; and a injector controller in operative communication with the injector to control the injector, the injector controller controlling injection of a fluid based upon at least one mathematical model, the mathematical model being determined by collecting data corresponding to a time enhancement curve resulting from injection of the contrast medium and being based at least in part upon a measured cardiac output of the patient, provided that the mathematical model is not determined by a continuous or a discrete-time Fourier deconvolution of the data. - View Dependent Claims (82)
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83. A method of controlling injection of a contrast medium into a patient using an injector in a medical imaging procedure using an imaging scanner, comprising:
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determining at least one mathematical model to predict a time enhancement response resulting from injection of the contrast medium, the mathematical model being based at least in part on a measured cardiac output of the patient; determining an injection protocol to approximate a predetermined time enhancement response in the patient by determining a constrained input solution to the mathematical model; and using the injection protocol to control the injector during the medical imaging procedure to control injection of the contrast medium into the patient to create an image of a region of interest. - View Dependent Claims (84, 85, 86, 87, 88, 89, 90, 91, 92)
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93. A system for effecting a medical procedure comprising:
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a sensing system to detect a patient response; an injector adapted to inject a pharmaceutical fluid; and a controller in operative communication with the injector to control the injector, the injector controller controlling injection of a fluid based upon at least one mathematical model, the mathematical model being determined by collecting data from the sensing system corresponding to a time response curve resulting from injection of the fluid and being based at least in part upon a measured cardiac output of the patient, provided that the mathematical model is not determined by solely a continuous or a discrete-time Fourier deconvolution of the data.
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94. An imaging system:
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an imager to create an image of a region of interest of a patient; an injector adapted to inject a contrast medium; and a controller in operative communication with the injector to control the injector, the injector controller controlling injection of the contrast medium based upon at least one mathematical model, the mathematical model being determined by collecting data from the imager corresponding to a time enhancement curve resulting from injection of the contrast medium and being based at least in part upon a measured cardiac output of the patient, provided that the mathematical model is not determined solely by a continuous or a discrete-time Fourier deconvolution of the data.
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95. A method of controlling injection of a pharmaceutical fluid into a patient using an injector having a controller in communicative connection with a computer memory in a medical procedure, comprising:
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collecting data corresponding to a patient response curve resulting from injection of the fluid; choosing at least one mathematical model from a plurality of mathematical models stored in the computer memory to describe the data; adapting the model to the collected data, the model being based at least in part upon a measured cardiac output of the patient; and controlling the injector via the controller during the medical procedure to control injection of the fluid into the patient to create patient response at least in part on the basis of the mathematical model.
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96. An imaging system:
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an imager to create an image of a region of interest of a patient; an injector adapted to inject a contrast medium; and a controller in operative communication with the injector to control the injector, the controller comprising at least one patient transfer function determined for the patient based upon data specific to the patient, and based at least in part upon a measured cardiac output of the patient, the at least one patient transfer function providing a time enhancement output for a given input, the controller comprising a processor to determine an injection procedure input for a desired time enhancement output using the at least one patient transfer function.
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Specification