APHERESIS OF A TARGET MOLECULE FROM CEREBROSPINAL FLUID
First Claim
1. A system for removing a target molecule from cerebrospinal fluid of a subject, the system comprising:
- a medium having a solid support to which an antibody directed to the target molecule is bound;
a reservoir for containing the medium;
a first catheter including a proximal end portion, an opening, and a lumen extending from the proximal end portion of the first catheter to the opening, wherein the first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir, and wherein the opening is configured to be placed in the cerebrospinal fluid of the subject; and
a second catheter including a proximal end portion, a delivery region and a lumen extending from the proximal end portion of the second catheter to the delivery region, wherein the second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen, and wherein the delivery region is configured to be placed in the cerebrospinal fluid of the subject.
1 Assignment
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Accused Products
Abstract
A system includes (i) a medium having a solid support to which an antibody directed to target molecule is bound, (ii) a reservoir for containing the medium, (iii) a first catheter, and (iv) a second catheter. The first catheter has a proximal end portion, an opening for removal of cerebrospinal fluid from a subject, and a lumen extending from the proximal end portion to the opening. The first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir. The second catheter has a proximal end portion, a delivery region for returning cerebrospinal fluid to the subject, and a lumen extending from the proximal end portion to the delivery region. The second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen.
35 Citations
22 Claims
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1. A system for removing a target molecule from cerebrospinal fluid of a subject, the system comprising:
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a medium having a solid support to which an antibody directed to the target molecule is bound; a reservoir for containing the medium; a first catheter including a proximal end portion, an opening, and a lumen extending from the proximal end portion of the first catheter to the opening, wherein the first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir, and wherein the opening is configured to be placed in the cerebrospinal fluid of the subject; and a second catheter including a proximal end portion, a delivery region and a lumen extending from the proximal end portion of the second catheter to the delivery region, wherein the second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen, and wherein the delivery region is configured to be placed in the cerebrospinal fluid of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for removing a target molecule from cerebrospinal fluid of a subject, the method comprising:
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withdrawing fluid from a first cerebrospinal fluid compartment of the subject; passing the withdrawn fluid through a reservoir of a medical device to remove the target molecule from the withdrawn fluid, wherein the reservoir contains a medium comprising a solid support to which an antibody directed to the target molecule is bound and wherein the media is capable of removing the target molecule from the cerebrospinal fluid; returning the withdrawn fluid with removed target molecule to a second cerebrospinal fluid compartment of the subject, wherein the first and second cerebrospinal fluid compartments are the same or different. - View Dependent Claims (14, 15, 16, 17)
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18. An implantable medical device comprising:
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a housing; a reservoir disposed in the housing; a medium disposed in the reservoir and comprising a solid surface to which antibodies directed to a target molecule are bound; a fluid outlet operably coupled to the reservoir; a fluid inlet operably coupled to the reservoir; and a pump disposed in the housing, operably coupled to the fluid inlet, the fluid outlet, and the reservoir, and configured to cause fluid to flow from the inlet through the reservoir and to the outlet. - View Dependent Claims (19, 20, 21, 22)
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Specification