DRUG DELIVERY PLATFORM UTILIZING HYDROGEL PUMPING MECHANISM

• US 20100030198A1
• Filed: 08/01/2008
• Published: 02/04/2010
• Est. Priority Date: 08/01/2008
• Status: Active Grant

• Current Assignee: Ratio, Inc., Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Ratio, Inc.
• Inventors: Chase, Kent, Escarcega, Tony, Beebe, David J., Moga, Benjamin J.
• Granted Patent: US 8,986,250 B2
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence

Abstract

A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a pressure source engageable with the reservoir. The pressure source is movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom. An output conduit is provided for transmitting the drug into the individual. An actuation mechanism is operatively connected to the pressure source and the output conduit. The actuation mechanism is movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output end of the output conduit is receivable in the individual.

Claims

1. A drug delivery platform for delivering a controlled infusion of a drug to an individual, comprising:

a reservoir for receiving the drug therein;

a pressure source engageable with the reservoir, the pressure source movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom;

an output conduit having an input and output;

an actuation mechanism operatively connected to the pressure source and the output conduit, the actuation mechanism movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output of the output conduit is receivable in the individual.

2. The drug delivery platform of claim 1 wherein the pressure source includes a hydrogel that expands in response to a predetermined stimulus.

3. The drug delivery platform of claim 2 wherein the predetermined stimulus is a fluid.

4. The drug delivery platform of claim 3 further comprising an initiation fluid wherein the actuation mechanism includes an initiation conduit having an input and output, the input of the initiation conduit communicating with the initiation fluid and the output of the initiation conduit communicating with the pressure source in response to the actuation mechanism in the actuated position.

5. The drug delivery platform of claim 4 further comprising a barrier between the initiation fluid and the pressure source, the barrier defining a channel network communicating with the pressure source and having an input that communicates with the output of the initiation conduit in response to the actuation mechanism in the actuated position.

6. The drug delivery platform of claim 5 further comprising a fluid diverter, the fluid diverter directing fluid from the output of the initiation conduit to the channel network.

7. The drug delivery platform of claim 5 wherein the channel network includes a plurality of circular, concentric channels.

8. The drug delivery platform of claim 1 wherein the actuation mechanism includes a biasing structure for urging the actuation mechanism towards the non-actuated position.

9. The drug delivery platform of claim 1 wherein the reservoir has first and second ends and includes an output adjacent the first end.

10. The drug delivery platform of claim 9 wherein the pressure source is positioned adjacent the second end of the reservoir.

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