DETECTING WORSENING HEART FAILURE BASED ON IMPEDANCE MEASUREMENTS
First Claim
1. A method comprising:
- periodically determining an impedance of a patient based on measured impedances;
comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previously determined impedances;
modifying an index over time based on the comparisons between the determined impedances and the reference impedances;
comparing the index to at least one threshold;
determining whether to provide an alert based on the comparison of the index to the at least one threshold; and
varying at least one other parameter over time that, in addition to the determined and reference impedances, affects a slope of the index.
1 Assignment
0 Petitions
Accused Products
Abstract
Techniques for processing impedance data to provide an early warning for heart failure decompensation are described. An example device may be configured to measure intrathoracic impedance values, and increment an index when a determined impedance is less than a reference impedance. The incrementing may be based on the difference between the reference impedances and the determined impedance. In some examples, the amount of incrementing is reduced based on a variability of the impedances, or increased over time so long as the index remains above a threshold, e.g., zero. In some examples, the manner is which the reference impedances are determined changes over time to, for example, address rapid changes in impedance after device or system implantation. In some examples, the index is compared to a threshold to determine whether to provide an alert. In some examples, two thresholds are used to provide hysteresis.
130 Citations
43 Claims
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1. A method comprising:
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periodically determining an impedance of a patient based on measured impedances; comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previously determined impedances; modifying an index over time based on the comparisons between the determined impedances and the reference impedances; comparing the index to at least one threshold; determining whether to provide an alert based on the comparison of the index to the at least one threshold; and varying at least one other parameter over time that, in addition to the determined and reference impedances, affects a slope of the index. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method comprising:
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periodically determining an impedance of a patient based on a plurality of measured impedances; comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previously determined impedances; determining an index based on the previous X or fewer comparisons, wherein X is a predetermined constant value; comparing the index to at least one threshold; and determining whether to provide an alert based on the comparison of the index to the at least one threshold. - View Dependent Claims (18, 19, 20)
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21. A method comprising:
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periodically determining an impedance of a patient based on a plurality of measured impedances; comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previously determined impedances; modifying an index over time based on the comparisons between the determined impedances and the reference impedances; comparing the index to a plurality of thresholds; and determining whether to provide an alert based on the comparison of the index to the plurality of thresholds. - View Dependent Claims (22)
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23. A system comprising:
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a plurality of electrodes; a medical device coupled to the electrodes that periodically measures an impedance of the patient; and a processor that; periodically determines an impedance value based on a plurality of the measured impedances, compares each of the determined impedance values to a respective reference impedance, wherein the respective reference impedance for each of the determined impedance values is determined based on a plurality of previously determined impedance values, modifies an index over time based on the comparisons between the determined impedance values and the reference impedances, compares the index to at least one threshold, determines whether to provide an alert based on the comparison of the index to the at least one threshold, and varies at least one other parameter over time that, in addition to the determined impedance values and reference impedances, affects a slope of the index. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A system comprising:
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a plurality of electrodes; a medical device coupled to the electrodes that periodically measures an impedance of a patient; and a processor that; periodically determines an impedance value based on a plurality of the measured impedances, compares each of the determined impedance values to a respective reference impedance, wherein the respective reference impedance for each of the determined impedance values is determined based on a plurality of previously determined impedance values; determines an index based on the previous X or fewer comparisons, wherein X is a predetermined constant value; compares the index to at least one threshold; and determines whether to provide an alert based on the comparison of the index to the at least one threshold. - View Dependent Claims (36, 37, 38)
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39. A system comprising:
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a plurality of electrodes; a medical device coupled to the electrodes that periodically measures an impedance of a patient; and a processor that; periodically determines an impedance value based on a plurality of the measured impedances, compares each of the determined impedance values to a respective reference impedance, wherein the respective reference impedance for each of the determined impedance values is determined based on a plurality of previous measured impedances; modifies an index over time based on the comparisons between the determined impedance values and the reference impedances; compares the index to a plurality of thresholds; and determines whether to provide an alert based on the comparison of the index to the plurality of thresholds. - View Dependent Claims (40)
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41. A system comprising:
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means for periodically determining an impedance of a patient based on a plurality of measured impedances; means for comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previous measured impedances; means for modifying an index over time based on the comparisons between the determined impedances and the reference impedances; means for comparing the index to at least one threshold; means for determining whether to provide an alert based on the comparison of the index to the at least one threshold; and means for varying at least one other parameter over time that, in addition to the determined and reference impedances, affects a slope of the index.
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42. A system comprising:
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means for periodically determining an impedance of a patient based on a plurality of measured impedances; means for comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previously determined impedances; means for determining an index based on the previous X or fewer comparisons, wherein X is a predetermined constant value; means for comparing the index to at least one threshold; and means for determining whether to provide an alert based on the comparison of the index to the at least one threshold.
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43. A system comprising:
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means for periodically determining an impedance of a patient based on a plurality of measured impedances; means for comparing each of the determined impedances to a respective reference impedance, wherein the respective reference impedance for each of the determined impedances is determined based on a plurality of previously determined impedances; means for modifying an index over time based on the comparisons between the determined impedances and the reference impedances; means for comparing the index to a plurality of thresholds; and means for determining whether to provide an alert based on the comparison of the index to the at least one threshold.
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Specification