METHODS AND APPARATUS RELATED TO BIOINFORMATICS DATA ANALYSIS

• US 20100030719A1
• Filed: 08/10/2009
• Published: 02/04/2010
• Est. Priority Date: 07/10/2008
• Status: Abandoned Application

• Current Assignee: Nodality Inc.
• Original Assignee: Nodality Inc.
• Inventors: Covey, Todd M., Evensen, Erik, Putta, Santosh K.
• Application Number:
  US12/538,643
• Publication Number:
  US 20100030719A1
• Time in Patent Office: Days
• US Class Current: 706/48
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

In one embodiment, one or more processor-readable media can be configured to store code representing instructions that when executed by one or more processors can cause the one or more processors to select a first relationship rule based on a first combination of parameters including a first parameter, and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category. A first statistical value can be defined based on a plurality of test values and based on the first relationship rule. A second statistical value can be defined based on a second relationship rule and based on a second combination of parameters. The second relationship rule can be selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters.

Claims

1. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

select a first relationship rule based on a first combination of parameters including a first parameter and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category;

define a first statistical value based on a plurality of test values and based on the first relationship rule; and

define a second statistical value based on a second relationship rule different from the first relationship rule and based on a second combination of parameters, the second relationship rule being selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters, the first parameter being different than the second parameter, the first combination of parameters having a portion of parameters equal to a portion of parameters of the second combination of parameters.

2. The one or more processor-readable media of claim 1, wherein the first relationship rule represents a biological relationship between at least two parameters included in the first combination of parameters.

3. The one or more processor-readable media of claim 1, wherein the plurality of test values are associated with a plurality of test substances, the first relationship rule defines an order for combining the plurality of test values to define the first statistical value.

4. The one or more processor-readable media of claim 1, wherein the hierarchical structure has a plurality of terminating parameters from the set of parameters, the plurality of test values are related to the terminating parameters.

5. The one or more processor-readable media of claim 1, wherein the biological category is a first biological category, the hierarchical structure is a first hierarchical structure, the first relationship rule is selected based on a second hierarchical structure within a second biological category mutually exclusive from the first biological category.

6. The one or more processor-readable media of claim 1, wherein the biological category is from a plurality of biological categories, the plurality of biological categories includes at least one of a protein category, a reagent category, a kinetic category, or a specimen category.

7. The one or more processor-readable media of claim 1, wherein at least one of the first statistical value or the second statistical value is based on a fluorescence intensity value produced at a cytometry device.

8. The one or more processor-readable media of claim 1, wherein the first parameter and the second parameter are hierarchically related via the hierarchical structure of the set of parameters.

9. The one or more processor-readable media of claim 1, wherein the second statistical value is defined in response to a user-triggered selection of the second parameter.

10. The one or more processor-readable media of claim 1, wherein the first relationship rule includes a first weight factor associated with the hierarchical position of the first parameter, the second relationship rule includes a second weight factor associated with the hierarchical position of the second parameter, the first weight factor is different than the second weight factor.

11. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

define a first statistical value associated with a test substance based on a combination of parameters, a parameter from the combination of parameters having a hierarchical position within a hierarchical structure of a set of parameters included in a biological category;

receive an indicator that the hierarchical position of the parameter has changed when the hierarchical structure is changed such that an annotation value associated with the parameter is included in the hierarchical structure, the annotation value being excluded from the hierarchical structure before the hierarchical structure is changed; and

define a second statistical value different than the first statistical value based on the changed hierarchical position.

12. The one or more processor-readable media of claim 11, wherein the parameter is a first parameter, the annotation value is associated with a second parameter that is at a hierarchical level of the hierarchical structure that is different than a hierarchical level of the first parameter within the hierarchical structure.

13. The one or more processor-readable media of claim 11, wherein the first statistical value is defined based on relationship rule, the relationship rule is defined based on empirical data related to the combination of parameters.

14. The one or more processor-readable media of claim 11, wherein the biological category is from a plurality of biological categories, each parameter from the combination of parameters is associated with at least one biological category from the plurality of biological categories.

15. The one or more processor-readable media of claim 11, wherein the first statistical value is calculated based on a plurality of test values related to the parameter.

16. The one or more processor-readable media of claim 11, wherein the combination of parameters are retrieved from a bioinformatics database.

17. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

define a first statistical value associated with a test substance based on combination of parameters, each parameter from the combination of parameters being associated with at least one biological category from a plurality of biological categories, the plurality of biological categories including at least a protein category and a reagent category;

modify the combination of parameters such that a parameter from the combination of parameters before the modifying is hierarchically related to a parameter from the modified combination of parameters; and

define a second statistical value based on the modified combination of parameters.

18. The one or more processor-readable media of claim 17, wherein the statistical value is defined based on a first relationship rule, the second statistical value is defined based on a second relationship rule, the first relationship rule and the second relationship rule have a hierarchical relationship correlated with the hierarchical relationship between the parameter from the combination of parameters before the modifying and the parameter from the modified combination of parameters.

19. The one or more processor-readable media of claim 17, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

define a first indicator based on the first statistical value and based on a condition associated with the first statistical value; and

define a second indicator different from the first indicator based on the second statistical value and based on the condition.

20. The one or more processor-readable media of claim 17, wherein the plurality of biological categories includes a kinetic category.

21. The one or more processor-readable media of claim 17, wherein the plurality of biological categories includes a specimen category.

22. The one or more processor-readable media of claim 17, wherein each parameter from the combination of parameters is from a unique biological category from the plurality of biological categories.

23. The one or more processor-readable media of claim 17, wherein the statistical value is retrieved from a bioinformatics database.

24. The one or more processor-readable media of claim 17, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

retrieve a plurality of fluorescence values from a bioinformatics database based on the combination of parameters, the first statistical value is calculated based on the plurality of fluorescence values.