Method of Cell Capture
First Claim
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1. A an analyte-manipulation device comprising:
- at least two coextensive, elongated, electrically-conductive members disposed in fixed, spaced relation;
an AC power source electrically connected to the electrically-conductive members and an electrical field gradient established by the AC power source between the members wherein the electrical field gradient is sufficient to retain a sample when the members are removed from a sample holder; and
a sample retained by the electrical gradient between the members wherein the members are outside of the sample holder from which the retained sample has been removed.
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Abstract
Embodiments of methods and devices are disclosed for the manipulation (e.g., concentration, purification, capture, trapping, location, transfer) of analytes, e.g., biomolecules, with respect to analyte-containing solutions, using one or more electric fields.
35 Citations
13 Claims
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1. A an analyte-manipulation device comprising:
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at least two coextensive, elongated, electrically-conductive members disposed in fixed, spaced relation; an AC power source electrically connected to the electrically-conductive members and an electrical field gradient established by the AC power source between the members wherein the electrical field gradient is sufficient to retain a sample when the members are removed from a sample holder; and a sample retained by the electrical gradient between the members wherein the members are outside of the sample holder from which the retained sample has been removed. - View Dependent Claims (2, 3)
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4. An analyte-manipulation device, comprising:
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a movable support; at least two coextensive, elongated, electrically-conductive members; said electrically-conductive members being held by said support for movement therewith; said electrically-conductive members having spaced-apart end regions, with an intervening region between said end regions defining a concentration zone; an AC power source electrically connected to said electrically-conductive members and an electrical field gradient established by the AC power source between said end regions effective to trap at least a portion of a polarizable analyte present in and electrolyte; and the at least a portion of the polarizable analyte retained by the electrical gradient between the members wherein the members are in a position removed from the sample holder. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification