COMPOSITION AND METHODS FOR PROMOTING HAIR GROWTH

• US 20100034787A1
• Filed: 10/15/2009
• Published: 02/11/2010
• Est. Priority Date: 08/30/2004
• Status: Abandoned Application

• Current Assignee: Histogen Incorporated
• Original Assignee: Histogen Incorporated
• Inventors: Naughton, Gail K.
• Application Number:
  US12/580,122
• Publication Number:
  US 20100034787A1
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 35/33 Fibroblasts
• CPC Class Codes: A61K 35/38 Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C12N 2501/415 Wnt; Frizzeled
• CPC Class Codes: C12N 2502/1323 Adult fibroblasts
• CPC Class Codes: C12N 2531/00 Microcarriers
• CPC Class Codes: C12N 2533/40 Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
• CPC Class Codes: C12N 5/0062 General methods for three-dimensional culture

Abstract

The present disclosure provides compositions and methods for promoting the growth of hair for cosmetic purposes as well as for treating disorders of hair growth. The compositions are conditioned media obtained from a three dimensional tissue that produces a combination of cellular factors effective to induce, promote, or enhance hair growth.

Claims

1. A method of promoting growth of hair, comprising:

administering intradermally or subcutaneously to a subject an effective amount of a composition comprising conditioned medium made from a three dimensional tissue.

2. The method of claim 1 in which the living cells comprise fibroblasts.

3. The method of claim 2 in which the fibroblasts are dermal fibroblasts.

4. The method of claim 1 in which the three dimensional tissue comprises a biocompatible, non-living material.

5. The method of claim 4 in which the biocompatible, non-living material comprises a biodegradable material.

6. The method of claim 5 in which the biodegradable material is polyglycolic acid, polylactide, polylactide-co-glycolic acid, catgut sutures, cellulose, gelatin, collagen, or dextran.

7. The method of claim 1 in which the biocompatible, non-living material comprises a non-biodegradable material.

8. The method of claim 7 in which the non-biodegradable material is polyamide, polyester, polystyrene, polypropylene, polyacrylate, polyvinyl, polycarbonate, polytetrafluoroethylene, nitrocellulose, or cotton.

9. The method of claim 1 in which the three dimensional tissue comprises a mesh.

10. The method of claim 1 in which the subject is afflicted with alopecia.

11. The method of claim 10 in which the alopecia is androgenetic alopecia.

12. The method of claim 10 in which the alopecia is alopecia areata.

13. The method of claim 10 in which the alopecia is chemotherapy induced alopecia.

14. The method of claim 10 in which the alopecia is radiation induced alopecia.

15. The method of claim 10 in which the alopecia is age-related alopecia.

16. The method of claim 1 in which the hair growth is that of a transplanted hair follicle.

17. The method of claim 1 in which the composition is administered adjunctively with at least one agent that induces skin vascularization.

18. The method of claim 17 in which the agent is minoxidil.

19. The method of claim 17 in which the agent is vascular endothelial growth factor (VEGF).

20. The method of claim 1 in which the composition is administered adjunctively with at least one agent that decreases levels of dihydrotestosterone in the skin.