MEDICAMENT FOR PROPHYLACTIC AND/OR THERAPEUTIC TREATMENT OF ALZHEIMER-TYPE DEMENTIA

• US 20100035927A1
• Filed: 01/22/2008
• Published: 02/11/2010
• Est. Priority Date: 01/23/2007
• Status: Abandoned Application

• Current Assignee: KOWA Company Limited, Public University Corporation Nagoya City University
• Original Assignee: KOWA Company Limited, Public University Corporation Nagoya City University
• Inventors: Matsukawa, Noriyuki, Ojika, Kosei
• Application Number:
  US12/523,436
• Publication Number:
  US 20100035927A1
• Time in Patent Office: Days
• US Class Current: 514/317
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A medicament for prophylactic and/or therapeutic treatment of Alzheimer-type dementia, which comprises donepezil hydrochloride and valproic acid or a salt thereof in combination.

Claims

1. A medicament for prophylactic and/or therapeutic treatment of Alzheimer-type dementia, which comprises donepezil hydrochloride and valproic acid or a salt thereof in combination.

2. The medicament according to claim 1, which is in the form of a pharmaceutical composition comprising donepezil hydrochloride and valproic acid or a salt thereof.

3. The medicament according to claim 1, which comprises donepezil hydrochloride and valproic acid or a salt thereof in combination in a form for administering donepezil hydrochloride and valproic acid or a salt thereof simultaneously, separately or successively.

4. The medicament according to claim 1, which is used for prophylactic and/or therapeutic treatment of behavioral and psychological symptoms of Alzheimer-type dementia.

5. The medicament according to claim 4, which is used for prophylactic and/or therapeutic treatment of the behavioral and psychological symptoms accompanied by problem behaviors.

8. The medicament according to claim 2, which is used for prophylactic and/or therapeutic treatment of behavioral and psychological symptoms of Alzheimer-type dementia.

9. The medicament according to claim 3, which is used for prophylactic and/or therapeutic treatment of behavioral and psychological symptoms of Alzheimer-type dementia.

10. The medicament according to claim 8, which is used for prophylactic and/or therapeutic treatment of the behavioral and psychological symptoms accompanied by problem behaviors.

11. The medicament according to claim 9, which is used for prophylactic and/or therapeutic treatment of the behavioral and psychological symptoms accompanied by problem behaviors.

6. A medicament for prolonging effective therapeutic period of donepezil hydrochloride for cognitive symptoms, which comprises valproic acid or a salt thereof as an active ingredient.

7. A medicament for prophylactic and/or therapeutic treatment of behavioral and psychological symptoms of Alzheimer-type dementia occurring during therapeutic treatment of Alzheimer-type dementia with donepezil hydrochloride, which comprises valproic acid or a salt thereof as an active ingredient.