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Oligoribonucleotides and Methods of use Thereof for Treatment of Cardiovascular Disease

  • US 20100035963A1
  • Filed: 09/06/2006
  • Published: 02/11/2010
  • Est. Priority Date: 09/09/2005
  • Status: Abandoned Application
First Claim
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1. A compound having the structure:

  • 5′

    (N)x-Z 3′

    (antisense strand)3′

    Z′

    -(N′

    )y 5′

    (sense strand)wherein each N and N′

    is a ribonucleotide which may be modified or unmodified in its sugar residue and (N)x and (N′

    )y is an oligomer in which each consecutive N or N′

    is joined to the next N or N′

    by a covalent bond;

    wherein each of x and y is an integer between 19 and 40;

    wherein each of Z and Z′

    may be present or absent, but if present is dTdT and is covalently attached at the 3′

    terminus of the strand in which it is present;

    and wherein the sequence of (N)x comprises an antisense sequence set forth in any of SEQ ID NOS;

    40-78.

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