Oligoribonucleotides and Methods of use Thereof for Treatment of Cardiovascular Disease
First Claim
Patent Images
1. A compound having the structure:
- 5′
(N)x-Z 3′
(antisense strand)3′
Z′
-(N′
)y 5′
(sense strand)wherein each N and N′
is a ribonucleotide which may be modified or unmodified in its sugar residue and (N)x and (N′
)y is an oligomer in which each consecutive N or N′
is joined to the next N or N′
by a covalent bond;
wherein each of x and y is an integer between 19 and 40;
wherein each of Z and Z′
may be present or absent, but if present is dTdT and is covalently attached at the 3′
terminus of the strand in which it is present;
and wherein the sequence of (N)x comprises an antisense sequence set forth in any of SEQ ID NOS;
40-78.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of one or more cardiovascular-related gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from a cardiovascular disorder or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient.
-
Citations
33 Claims
-
1. A compound having the structure:
-
5′
(N)x-Z 3′
(antisense strand)3′
Z′
-(N′
)y 5′
(sense strand)wherein each N and N′
is a ribonucleotide which may be modified or unmodified in its sugar residue and (N)x and (N′
)y is an oligomer in which each consecutive N or N′
is joined to the next N or N′
by a covalent bond;wherein each of x and y is an integer between 19 and 40; wherein each of Z and Z′
may be present or absent, but if present is dTdT and is covalently attached at the 3′
terminus of the strand in which it is present;and wherein the sequence of (N)x comprises an antisense sequence set forth in any of SEQ ID NOS;
40-78. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 18, 27, 31, 33)
-
-
2. (canceled)
-
15. A vector capable of expressing a compound having the structure:
-
5′
(N)x-Z 3′
(antisense strand)3′
Z′
-(N′
)y 5′
(sense strand)wherein each N and N′
is a ribonucleotide which may be modified or unmodified in its sugar residue and (N)x and (N′
)y is an oligomer in which each consecutive N or N′
is joined to the next N or N′
by a covalent bond;wherein each of x and y is an integer between 19 and 40; wherein each of Z and Z′
may be present or absent, but if present is dTdT and is covalently attached at the 3′
terminus of the strand in which it is present;and wherein the sequence of (N)x comprises an antisense sequence set forth in any of SEQ ID NOS;
40-78.
-
-
17. (canceled)
-
19-26. -26. (canceled)
-
28-30. -30. (canceled)
-
32. (canceled)
Specification