METHODS AND SYSTEMS FOR ASSESSMENT OF CLINICAL INFERTILITY
First Claim
1. A method of evaluating a female subject for an in vitro fertilization procedure, comprising:
- obtaining items of information from a female subject to provide a profile for said female subject, wherein each item of information relate to preselected patient variables;
comparing said profile for said female subject to a library of known profile patterns known to be indicative of responsiveness to an in vitro fertilization procedure using an algorithm based upon said preselected patient variables,wherein said comparing provides an evaluation of said female subject for an in vitro fertilization procedure.
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Accused Products
Abstract
Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.
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Citations
90 Claims
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1. A method of evaluating a female subject for an in vitro fertilization procedure, comprising:
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obtaining items of information from a female subject to provide a profile for said female subject, wherein each item of information relate to preselected patient variables; comparing said profile for said female subject to a library of known profile patterns known to be indicative of responsiveness to an in vitro fertilization procedure using an algorithm based upon said preselected patient variables, wherein said comparing provides an evaluation of said female subject for an in vitro fertilization procedure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of evaluating a female subject for an in vitro fertilization procedure, comprising:
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obtaining items of information from a female subject to provide a profile for said female subject, wherein each item of information relate to preselected patient variables; determining an expression level of one or more infertility indicator genes; comparing said profile for said female subject to a library of known profile patterns known to be indicative of responsiveness to an in vitro fertilization procedure using an algorithm based upon said preselected patient variables; and comparing said expression level of said one or more infertility indicator genes to a control gene expression profile known to be indicative of responsiveness to an in vitro fertilization procedure wherein said comparing said profile for said female subject and said expression level of said one or more infertility indicator genes provides an evaluation of said female subject for an in vitro fertilization procedure. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A system for analysis of data in evaluating a female subject for an in vitro fertilization procedure, comprising:
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a computing environment; an input device, connected to the computing environment, to receive data from a user, wherein the data received comprises items of information from a female subject to provide a profile for said female subject, wherein each item of information relate to preselected patient variables, an output device, connected to the computing environment, to provide information to the user; and a computer readable storage medium having stored thereon at least one algorithm to provide for comparing the profile for the female subject to a library of known profile patterns known to be indicative of responsiveness to an in vitro fertilization procedure, wherein the system provides results that can be used for generation of a report providing an analysis of data in evaluating a female subject for an in vitro fertilization procedure. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90)
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Specification