SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM
First Claim
1. In a glucose sensing system comprising a glucose sensor configured for producing an output representative of glucose concentration in a host and processing circuitry configured to process the output, a method for processing data from the output, the method comprising:
- generating at least one data stream from the glucose sensor output;
defining a range of data stream values with a time series analysis;
detecting a signal artifact comprising transient non-glucose dependent signal losses that have a higher amplitude than system noise when values of the data stream fall outside of the range; and
generating at least one estimated data stream or data stream portion to reduce or replace signal loss caused by the detected signal artifact.
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Abstract
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
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Citations
19 Claims
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1. In a glucose sensing system comprising a glucose sensor configured for producing an output representative of glucose concentration in a host and processing circuitry configured to process the output, a method for processing data from the output, the method comprising:
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generating at least one data stream from the glucose sensor output; defining a range of data stream values with a time series analysis; detecting a signal artifact comprising transient non-glucose dependent signal losses that have a higher amplitude than system noise when values of the data stream fall outside of the range; and generating at least one estimated data stream or data stream portion to reduce or replace signal loss caused by the detected signal artifact. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A glucose sensor system for monitoring a glucose concentration in a host, the system comprising:
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a continuous glucose sensor configured to produce a data stream; a signal artifact detection module configured to define a range of data stream values with a time series analysis and to detect a signal artifact caused by transient non-glucose dependent signal losses that have a higher amplitude than system noise in the data stream noise when values of the data stream fall outside of the range; and a signal estimation module configured to generate an estimated data stream or data stream portion to reduce or replace the signal artifact. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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Specification