Magnetic Nanoparticles Compositions and Uses Thereof
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Abstract
The present invention relates to the use of a biocompatible nanoparticle or nanoparticle aggregate, in combination with an external non-oscillating magnetic field, wherein said nanoparticle comprises: a) a core comprising magnetic material; b) a biocompatible shell surrounding the core, and, optionally; c) a labelling agent wherein the outer diameter of the shell is less than about 100 nm, to prepare a composition, wherein the composition is deprived of any cell targeting means. The present invention further relates to the compositions thus obtained and to their uses in the field of human health, for the treatment of cancer, or in diagnostic (imaging for example), for the monitoring of tumor evolution.
14 Citations
46 Claims
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1-23. -23. (canceled)
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24. A method for treating a cancer comprising:
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(a) the administration to a patient suffering of a cancer of a composition comprising a biocompatible nanoparticle or nanoparticle aggregate, wherein said nanoparticle lacks a targeting means and comprises a core comprising ferromagnetic material and a biocompatible shell surrounding the core, wherein the outer diameter of the shell is less than about 100 nm; and (b) exposing the patient to an external non-oscillating magnetic field. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 37)
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34. A method for treating, detecting or visualizing a cancer cell, a tissue or an organ comprising:
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(a) the administration to a patient a composition comprising a biocompatible nanoparticle or nanoparticle aggregate, wherein said nanoparticle lacks a targeting means and comprises a core, a biocompatible shell surrounding the core and a labelling agent, wherein the core comprises ferromagnetic material and wherein the outer diameter of the shell is less than about 100 nm; and (b) exposing the patient to an external magnetic field. - View Dependent Claims (38)
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39. A pharmaceutical composition comprising a biocompatible nanoparticle or nanoparticle aggregate lacking a targeting means and comprising:
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(a) a core comprising ferromagnetic material; and (b) a biocompatible shell surrounding the core, wherein the outer diameter of the shell is less than about 100 nm, in association with a biocompatible carrier. - View Dependent Claims (40, 41, 42)
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43. A diagnostic composition comprising a biocompatible nanoparticle or nanoparticle aggregate lacking a targeting means and comprising:
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(a) a core comprising ferromagnetic material; (b) a biocompatible shell surrounding the core; and (c) a labelling agent, wherein the outer diameter of the shell is less than about 100 nm and preferably less than 50 nm in association with a biocompatible carrier. - View Dependent Claims (44, 45, 46)
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Specification