METHOD OF TREATING BONE CANCER

• US 20100040667A1
• Filed: 09/06/2007
• Published: 02/18/2010
• Est. Priority Date: 09/07/2006
• Status: Abandoned Application

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Pfirrmann, Rolf W.
• Application Number:
  US12/440,347
• Publication Number:
  US 20100040667A1
• Time in Patent Office: Days
• US Class Current: 424/426
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/54 having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
• CPC Class Codes: A61K 31/541 Non-condensed thiazines containing further heterocyclic rings
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

A method of treatment for treating, at least partially preventing, inhibiting or reducing growth of a bone tumor in a subject, including at least partially removing a bone tumor from a subject and contacting an area of bone adjacent to where the tumor was at least partially removed with a gel containing a tumor growth-inhibiting methylol transfer agent.

Claims

1. A method of treatment for treating, at least partially preventing, inhibiting or reducing growth of a bone tumor in a subject, comprising at least partially removing a bone tumor from a subject and contacting an area of bone adjacent to where the tumor was at least partially removed with a gel containing a tumor growth-inhibiting methylol transfer agent.

2. The method of claim 1 wherein said gel is resorbable.

3. The method of claim 1 wherein said gel is an aqueous gel comprising cross-linked fibrous protein.

4. The method of claim 1 wherein said gel comprises gelatin.

5. The method of claim 4 wherein said gel is at least partially cross-linked.

6. The method of claim 1 wherein said methylol transfer agent comprises taurolidine, taurultam, a mixture thereof, or an equilibrium thereof.

7. The method of claim 6 wherein said methylol transfer agent is at a concentration within said gel of about 0.5-5% by weight.

8. The method of claim 7 wherein said concentration is about 1-4%.

9. The method of claim 7 wherein said concentration is about 2-4%.

10. The method of claim 7 wherein said concentration is about 2-3% solubilized methylol transfer agent in said gel, and about 1-2% crystalline methylol transfer agent in said gel.

11. The method of claim 1 wherein said gel comprises granules.

12. The method of claim 11 wherein said granules have a size within a range of about 1-10 mm.

13. The method of claim 12 wherein said size is about 1.5-5 mm.

14. The method of claim 1 wherein said gel is in a form of a shaped solid.

15. The method of claim 14 wherein said shaped solid is a rod.

16. The method of claim 1 wherein said area is a cavity within said bone, and said gel is mixed with autologous bone material, synthetic bone mineral, natural bone mineral or a combination thereof and the thus formed mixture is filled into said cavity.

17. The method of claim 1 further comprising mixing bone marrow cells with said gel prior to contacting said area.

18. The method of claim 1 wherein said area is a cavity in said bone, said gel is filled into said cavity after at least partially removing said tumor, a drain tube is installed into the subject leading from the cavity to outside of the subject, and the cavity is surgically closed.

19. The method of claim 18 further comprising instilling additional said gel into said cavity through said drain tube.

20. The method of claim 1 wherein said tumor is a sarcoma.

21. The method of claim 1 wherein said tumor is an osteosarcoma.