METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE PERFORMANCE

• US 20100041621A1
• Filed: 08/14/2009
• Published: 02/18/2010
• Est. Priority Date: 08/15/2008
• Status: Active Application

• Current Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Original Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Inventors: Renshaw, Perry, Yurgelun-Todd, Deborah
• Application Number:
  US12/541,504
• Publication Number:
  US 20100041621A1
• Time in Patent Office: Days
• US Class Current: 514/51
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/13 Nucleic acids or derivatives thereof A23L33/145 takes precedence
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/175 Amino acids

Abstract

The invention provides methods and compositions for improving cognitive performance involving administration of a cytidine-containing or uridine-containing compound to a neuropsychologically healthy human.

Claims

1. A method of improving cognitive performance in a neuropsychologically healthy human, said method comprising administering to said human an effective amount of a cytidine-containing or uridine-containing compound.

2. The method of claim 1, wherein said cognitive performance is selected from attention, attentional control, accuracy under time pressure, working memory, and learning aptitude.

3. The method of claim 2, wherein said learning aptitude is verbal learning aptitude.

4. The method of claim 1, wherein said human is a child.

5. The method of claim 1, wherein said human is an adult between 21 and 60 years of age.

6. The method of claim 1, wherein said compound is formulated in a nutraceutical composition and is administered orally.

7. The method of claim 1, wherein said administering is chronic.

8. The method of claim 1, wherein said cytidine-containing compound is CDP.

9. The method of claim 1, wherein said cytidine-containing compound is CDP-choline.

10. The method of claim 9, wherein said effective amount is equal to or less than 500 mg, 250 mg, or 100 mg.

11. The method of claim 6, wherein said nutraceutical composition is a drink, tablet, or capsule.

12. The method of claim 6, wherein said nutraceutical composition further comprises one or more of the group consisting of vitamin B6, vitamin B12, niacin, folic acid, tyrosine, phenylalanine, taurine, malic acid, glucuronolactone, and caffeine.

13. The method of claim 12, wherein said compound is CDP-choline, and said nutraceutical composition is a drink.

14. The method of claim 6, wherein said nutraceutical composition further comprises a phospholipid precursor.

15. A nutraceutical composition comprising a cytidine-containing or uridine-containing compound in an amount effective to improve the cognitive performance of a neuropsychologically healthy human.

16. The composition of claim 15, wherein said cytidine-containing compound is CDP.

17. The composition of claim 15, wherein said cytidine-containing compound is CDP-choline.

18. The composition of claim 17, wherein said amount is equal to or less than 500 mg, 250 mg, or 100 mg.

19. The composition of claim 15, further comprising one or more of the group consisting of vitamin B6, vitamin B12, niacin, folic acid, taurine, malic acid, glucuronolactone, tyrosine, phenylalanine, and caffeine.

20. The composition of claim 15, further comprising a phospholipid precursor.