DRUG DELIVERY IMPLANTS

• US 20100042214A1
• Filed: 08/28/2009
• Published: 02/18/2010
• Est. Priority Date: 08/13/2008
• Status: Active Grant

• Current Assignee: SMed TA/TD, LLC. (Sites Medical LLC)
• Original Assignee: SMed TA/TD, LLC. (Sites Medical LLC)
• Inventors: Stalcup, Gregory C., Nebosky, Paul S., Zimmerman, Sarah L.
• Granted Patent: US 9,616,205 B2
• Time in Patent Office: Days
• US Class Current: 623/16.110
• CPC Class Codes: A61B 17/56 Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• CPC Class Codes: A61B 17/60 for external osteosynthesis, e.g. distractors, contractors
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61B 17/7061 for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange intraosseous injection devices A61B17/3472
• CPC Class Codes: A61B 17/7098 wherein the implant is permeable or has openings, e.g. fenestrated screw hollow surgical screws A61B17/864
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 17/8625 Shanks, i.e. parts contacting bone tissue
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61C 8/0018 characterised by the shape
• CPC Class Codes: A61C 8/0039 in the form of hollow cylinder with an open bottom
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30 Joints
• CPC Class Codes: A61F 2/34 Acetabular cups
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2/389 Tibial components A61F2/3868 takes precedence
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2002/30593 : hollow
• CPC Class Codes: A61F 2002/30672 : temporary
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/3068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2002/3071 : Identification means; Administration of patients
• CPC Class Codes: A61F 2002/30784 : Plurality of holes
• CPC Class Codes: A61F 2002/3092 : having an open-celled or open-pored structure
• CPC Class Codes: A61F 2250/0068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0089 : coded with symbols, e.g. dots, numbers, letters, words
• CPC Class Codes: A61M 2210/02 : Bones
• CPC Class Codes: A61M 31/002 : Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 : specially adapted for implantation

Abstract

An orthopaedic implant system includes an orthopaedic implant implantable at a selected location within a corporeal body and configured for delivering at least one therapeutic agent to the corporeal body, the implant defining a reservoir and a plurality of channels, the reservoir configured for receiving the at least one therapeutic agent, the plurality of channels configured for conveying the at least one therapeutic agent from the reservoir to a treatment site relative to the corporeal body, the implant being at least one of an internal fixation device and a porous device.

Claims

1. An orthopaedic implant system, comprising:

an orthopaedic implant implantable at a selected location within a corporeal body and configured for delivering at least one therapeutic agent to said corporeal body, said implant defining a reservoir and a plurality of channels, said reservoir configured for receiving said at least one therapeutic agent, said plurality of channels configured for conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body, said implant being at least one of an internal fixation device and a porous device.

2. The orthopaedic implant system of claim 1, wherein said internal fixation device includes an exterior surface, said plurality of channels fluidly communicating said reservoir with said exterior surface and thereby being configured for conveying said at least one therapeutic agent from said reservoir to said exterior surface.

3. The orthopaedic implant system of claim 1, wherein said internal fixation device is a bone screw including an exterior surface, a head, and a threaded section, said head including at least one of said plurality of channels, said threaded section including at least one of said plurality of channels, said plurality of channels fluidly communicating said reservoir with said exterior surface and thereby being configured for conveying said at least one therapeutic agent from said reservoir to said exterior surface.

4. The orthopaedic implant system of claim 1, further including a second reservoir implantable at said selected location within said corporeal body and including a plurality of delivery holes configured for delivering said at least one therapeutic agent to said corporeal body, said internal fixation device including an exterior surface, said second reservoir at least partially surrounding and being attached to said internal fixation device, said internal fixation device including an ingress channel configured for conveying said at least one therapeutic agent from said second reservoir to said reservoir of said internal fixation device, said plurality of channels fluidly communicating said reservoir of said internal fixation device with said exterior surface and thereby being configured for conveying said at least one therapeutic agent from said reservoir of said internal fixation device to said exterior surface.

5. The orthopaedic implant of claim 4, wherein said second reservoir is elastic and is thereby configured for expelling said at least one therapeutic agent at least one of through said plurality of holes and into said ingress channel.

6. The orthopaedic implant of claim 4, wherein said second reservoir is rigid and forms a permeable membrane configured for controllably releasing said at least one therapeutic agent therefrom.

7. The orthopaedic implant system of claim 1, further including a second reservoir implantable at said selected location within said corporeal body and including a plurality of delivery holes configured for delivering said at least one therapeutic agent to said corporeal body, said internal fixation device being a bone screw including a head, a threaded section, and an exterior surface, said second reservoir surrounding and being attached to said head, said head including an ingress channel configured for conveying said at least one therapeutic agent from said second reservoir to said reservoir of said bone screw, said threaded section including said plurality of channels, said plurality of channels fluidly communicating said reservoir of said bone screw with said exterior surface and thereby being configured for conveying said at least one therapeutic agent from said reservoir of said bone screw to said exterior surface.

8. The orthopaedic implant system of claim 1, further including a second reservoir and a tubular element, said second reservoir being implantable within said corporeal body remote from said internal fixation device, said tubular element being implantable within said corporeal body, said internal fixation device including an exterior surface, said second reservoir coupled with said internal fixation device via said tubular element and thereby configured for delivering said at least one therapeutic agent to said exterior surface via said tubular element, said reservoir, and said plurality of channels.

9. The orthopaedic implant system of claim 8, wherein said internal fixation device is a bone screw.

10. The orthopaedic implant system of claim 1, wherein said porous device is one of partially porous and completely porous.

11. The orthopaedic implant system of claim 1, wherein said porous device is one of a natural and an artificial bone graft including a plurality of pores forming said reservoir and said plurality of channels, said porous device being configured for receiving at least one of bone and soft tissue ingrowth therein.

12. The orthopaedic implant system of claim 1, wherein said porous device is a natural bone graft which is configured for being implanted in a bone and for delivering said at least one therapeutic agent at least one of directly within a joint capsule and to said bone.

13. The orthopaedic implant system of claim 1, wherein said implant includes only one said reservoir.

14. The orthopaedic implant system of claim 1, wherein said reservoir is configured for being refilled with said at least one therapeutic agent after said implant has been implanted in said corporeal body.

15. The orthopaedic implant system of claim 1, wherein said implant is configured for delivering a plurality of therapeutic agents to said corporeal body via said reservoir and said plurality of channels.

16. The orthopaedic implant system of claim 1, wherein said reservoir is configured for receiving said at least one therapeutic agent after said implant has been implanted in said corporeal body and then communicating said at least one therapeutic agent via said plurality of channels to said treatment site.

17. A method of using an orthopaedic implant system, said method comprising the steps of:

providing an orthopaedic implant defining a reservoir and a plurality of channels, said implant being at least one of an internal fixation device and a porous device;

implanting said implant at a selected location within said corporeal body;

receiving at least one therapeutic agent in said reservoir;

conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body via said plurality of channels; and

delivering said at least one therapeutic agent to said corporeal body.

18. The method of claim 17, wherein said internal fixation device includes an exterior surface, said plurality of channels fluidly communicating said reservoir with said exterior surface and thereby conveying said at least one therapeutic agent from said reservoir to said exterior surface.

19. The method of claim 17, wherein said internal fixation device is a bone screw including an exterior surface, a head, and a threaded section, said head including at least one of said plurality of channels, said threaded section including at least one of said plurality of channels, said plurality of channels fluidly communicating said reservoir with said exterior surface and thereby conveying said at least one therapeutic agent from said reservoir to said exterior surface.

20. The method of claim 17, further including implanting a second reservoir at said selected location within said corporeal body, delivering said at least one therapeutic agent to said corporeal body via a plurality of holes in said second reservoir, said internal fixation device including an exterior surface, said second reservoir at least partially surrounding and being attached to said internal fixation device, said internal fixation device including an ingress channel conveying said at least one therapeutic agent from said second reservoir to said reservoir of said internal fixation device, said plurality of channels fluidly communicating said reservoir of said internal fixation device with said exterior surface and thereby conveying said at least one therapeutic agent from said reservoir of said internal fixation device to said exterior surface.

21. The method of claim 20, wherein said second reservoir is elastic and thereby expels said at least one therapeutic agent at least one of through said plurality of holes and into said ingress channel.

22. The method of claim 20, wherein said second reservoir is rigid and forms a permeable membrane which controllably releases said at least one therapeutic agent therefrom.

23. The method of claim 17, further including implanting a second reservoir at said selected location within said corporeal body, delivering said at least one therapeutic agent to said corporeal body via a plurality of holes in said second reservoir, said internal fixation device being a bone screw including a head, a threaded section, and an exterior surface, said second reservoir surrounding and being attached to said head, said head including an ingress channel conveying said at least one therapeutic agent from said second reservoir to said reservoir of said bone screw, said threaded section including said plurality of channels, said plurality of channels fluidly communicating said reservoir of said bone screw with said exterior surface and thereby conveying said at least one therapeutic agent from said reservoir of said bone screw to said exterior surface.

24. The method of claim 17, further including implanting a second reservoir within said corporeal body remote from said internal fixation device, implanting a tubular element within said corporeal body, said second reservoir coupled with said internal fixation device via said tubular element and thereby delivering said at least one therapeutic agent to an exterior surface of said internal fixation device via said tubular element, said reservoir, and said plurality of channels.

25. The method of claim 24, wherein said internal fixation device is a bone screw.

26. The method of claim 17, wherein said porous device is one of partially porous and completely porous.

27. The method of claim 17, wherein said porous device is one of a natural and an artificial bone graft including a plurality of pores forming said reservoir and said plurality of channels, said porous device receiving at least one of bone and soft tissue ingrowth therein.

28. The method of claim 17, wherein said porous device is a natural bone graft which is configured for being implanted in a bone and for delivering said at least one therapeutic agent at least one of directly within a joint capsule and to said bone.

29. The method of claim 17, wherein said implant includes only one said reservoir.

30. The method of claim 17, further including refilling said reservoir with said at least one therapeutic agent after said implant has been implanted in said corporeal body.

31. The method of claim 17, further including delivering a plurality of therapeutic agents to said corporeal body via said reservoir and said plurality of channels.

32. The method of claim 17, wherein said reservoir receives said at least one therapeutic agent after said implant has been implanted in said corporeal body and then communicates said at least one therapeutic agent via said plurality of channels to said treatment site.

33. A method of using an orthopaedic implant, said method comprising the steps of:

providing an orthopaedic implant body defining at least one pathway;

receiving at least one therapeutic agent by said implant body;

implanting the orthopaedic implant at a selected location within a corporeal body;

conveying said at least one therapeutic agent from said implant body to a treatment site relative to said corporeal body via said at least one pathway using pressure generated by said corporeal body to mechanically force said at least one therapeutic agent from said implant body to said treatment site.

34. The method of claim 33, wherein said implant body is an elastic bladder.

35. The method of claim 33, wherein said implant body is a spongy element including a plurality of pores, said at least one pathway formed by at least one said pore.

36. A method of using an orthopaedic implant, said method comprising the steps of:

providing an orthopaedic implant defining a reservoir and a plurality of channels;

implanting said implant at a selected location within a corporeal body, said implant being implanted into soft tissue of said corporeal body;

receiving at least one therapeutic agent in said reservoir;

conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body via said plurality of channels; and

delivering said at least one therapeutic agent to said corporeal body.

37. The method of claim 36, wherein said implant is implanted into at least one of a muscle, a ligament, a tendon, a joint capsule, a fibrous tissue, fat, a membrane, and cartilage of said corporeal body.