METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS

• US 20100042351A1
• Filed: 07/10/2009
• Published: 02/18/2010
• Est. Priority Date: 07/10/2008
• Status: Abandoned Application

• Current Assignee: Nodality Inc.
• Original Assignee: Nodality Inc.
• Inventors: Francis-Lang, Helen, Purvis, Norman B. JR., Francis-Lang, Malcolm, Spellmeyer, David C., Soper, David M., Farrow, Darwin A., Friedland, Barton J., Mccarthy, Justin W., Putta, Santosh K., Rosen, David B., Covey, Todd M.
• Application Number:
  US12/501,274
• Publication Number:
  US 20100042351A1
• Time in Patent Office: Days
• US Class Current: 702/108
• CPC Class Codes: G01N 15/1404 Handling flow, e.g. hydrodynamic focusing
• CPC Class Codes: G01N 35/00663 of consumables
• CPC Class Codes: G01N 35/00712 Automatic status testing, e.g. at start-up or periodic

Abstract

In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.

Claims

1. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

define experimental parameter values associated with a plurality of test sites within a testing substrate based on a quantity value of a sample, the experimental parameter values defining at least a portion of an experimental plan associated with the sample;

receive an updated quantity value of the sample; and

identify a test site from the plurality of test sites as a fall-off test site based on the updated quantity value of the sample.

2. The one or more processor-readable media of claim 1, wherein the plurality of test sites define an experimental layout within the testing substrate,

the one or more processor-readable media further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

change a status of the test site from an available status to an unavailable status in response to the identifying; and

modify the experimental layout based on the plurality of test sites after the removing.

3. The one or more processor-readable media of claim 2, wherein the experimental layout is configured for analysis by a flow cytometry device.

4. The one or more processor-readable media of claim 2, wherein the experimental layout is defined based on an experimental layout template retrieved from a template database.

5. The one or more processor-readable media of claim 1, wherein the sample is a biological sample.

6. The one or more processor-readable media of claim 1, wherein the updated quantity value of the sample is defined in response to a prompt triggered by a workflow.

7. The one or more processor-readable media of claim 6, wherein the workflow is defined based on a standard operating procedure.

8. The one or more processor-readable media of claim 1, wherein at least a portion of the experimental parameter values are defined based on a pre-defined recipe.

9. The one or more processor-readable media of claim 1, wherein the experimental parameter value is defined based on an automatic unit conversion procedure.

10. The one or more processor-readable media of claim 1, wherein at least one of the experimental parameter values represents a chemical composition.

11. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

send an indicator of an availability of a sample from a sample pool stored in a physical inventory, the sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool;

receive an indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites;

retrieve a rule from a rule database based on an experimental parameter value associated with the first test site; and

modify at least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site based on a condition within the rule being satisfied.

12. The one or more processor-readable media of claim 11, wherein the attribute of the sample is a hidden attribute from a plurality of hidden attributes.

13. The one or more processor-readable media of claim 11, wherein the attribute of the sample is included in an experiment file associated with the first test site when a status of the attribute is changed from a hidden status to an unhidden status.

14. The one or more processor-readable media of claim 11, wherein the sample pool is a first sample pool, the sample is included in a second sample pool based on the attribute of the sample satisfying a condition associated with the second sample pool.

15. The one or more processor-readable media of claim 11, wherein the sample is selected from the sample pool based on a scientific question associated with a clinical study.

16. The one or more processor-readable media of claim 11, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

modify an experimental layout associated with the array of test sites in response to the receiving.

17. The one or more processor-readable media of claim 11, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

define an experiment file based on the experimental parameter value associated with a first test site after the modifying.

18. The one or more processor-readable media of claim 11, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

receive an indicator that a portion of a workflow has been completed, at least one of the retrieving or the modifying is performed after the receiving of the indicator.

19. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

receive a first attribute associated with a substance selected for analysis at a test site from an array of test sites;

retrieve a condition from a knowledge database based on the first attribute; and

retrieve a condition associated with a rule based on the first attribute, the rule being defined based on information included in a knowledge database; and

send a notification in response to a condition related to an interaction between the first attribute and a second attribute being satisfied.

20. The one or more processor-readable media of claim 19, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

modify an experimental layout associated with the array of test sites in response to the condition being satisfied.

21. The one or more processor-readable media of claim 19, further storing code representing instructions that when executed by one or more processors cause the one or more processors to:

send an indicator that a sample within an inventory is available; and

associate the sample with the test site, the attribute represents a chemical property of the sample.

22. The one or more processor-readable media of claim 19, wherein the first attribute is associated with a first reagent included in the substance, the second attribute is associated with a second reagent included in the substance.

23. The one or more processor-readable media of claim 19, wherein the first attribute is associated with a first reagent included in the substance, the second attribute is associated with a sample included in the substance.

24. The one or more processor-readable media of claim 19, wherein the substance is a first substance, the test site is a first test site, the second attribute is associated with a second substance selected for analysis at a second test site from the array of test sites.

25. The one or more processor-readable media of claim 19, wherein the condition is related to a chemical conflict.

26. The one or more processor-readable media of claim 19, wherein the condition is related to a detection conflict.

27. The one or more processor-readable media of claim 19, wherein the condition is related to an empirical finding stored in the knowledge database.

28. One or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

receive a set of parameter values defining a visualization layout of a plurality of values, each value from the plurality of values being defined based on data related to an experiment performed at a flow cytometer;

trigger display of the plurality of values within the visualization layout based on the set of parameter values;

modify, after display of the plurality of values has been triggered, at least a portion of the data in response to an instruction; and

update a value from the plurality of values displayed within the visualization layout in response to the data being modified.

29. The one or more processor-readable media of claim 28, wherein the data is related to a plurality of samples processed at the flow cytometer, the value from the plurality of values is calculated based on statistical combination of a portion of the data.

30. The one or more processor-readable media of claim 28, wherein the visualization layout includes at least one of a graphical visualization layout, a spatial visualization layout, or a heat map.

31. The one or more processor-readable media of claim 28, wherein the instruction is defined based on a flow cytometry data analysis algorithm.

32. The one or more processor-readable media of claim 28, wherein the data is modified based on a gate boundary.

33. The one or more processor-readable media of claim 28, wherein the visualization layout is defined based on at least one of a plurality of filters or a predefined user preference.