Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods
First Claim
1. A graft collar for fixing tendon to bone in a subject, wherein said graft collar comprises a sheet of biopolymer mesh or polymer-fiber mesh.
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Accused Products
Abstract
This application describes apparatuses and methods for musculoskeletal tissue engineering. Specifically, graft collar and scaffold apparatuses are provided for promoting fixation of musculoskeletal soft tissue to bone.
This application provides for graft collars comprising biopolymer mesh and/or polymer-fiber mesh for fixing tendon to bone. In one aspect, the graft collar comprises more than one region, wherein the regions can comprise different materials configured to promote integration of and the regeneration of the interfacial region between tendon and bone.
This application also provides for scaffold apparatuses and methods for fixing musculoskeletal soft tissue to bone. The scaffold apparatus is multiphasic, preferably triphasic, and each phase is configured promote growth and proliferation of a different cell and its associated tissue. In one aspect, the scaffold apparatus is triphasic, with phases comprising materials to promote growth and proliferation of fibroblasts, chondroblasts, and osteoblasts. In addition, an apparatus comprising two portions, each of said portion being the scaffold apparatus described above is provided, wherein each of said portion encases one end of a soft tissue graft. Further, a triphasic interference screw is provided.
This application further provides apparatuses and methods for inducing formation of fibrocartilage comprising wrapping a graft collar with polymer-fiber mesh configured to apply compression to the graft collar. In another aspect, the polymer-fiber is applied directly to the graft to apply compression to the graft.
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Citations
211 Claims
- 1. A graft collar for fixing tendon to bone in a subject, wherein said graft collar comprises a sheet of biopolymer mesh or polymer-fiber mesh.
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24. A graft collar for fixing tendon to bone in a subject, wherein the graft collar comprises:
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a) a first region comprising a biopolymer mesh or a polymer-fiber mesh and hydrogel; and b) a second region adjoining the first region and comprising a biopolymer mesh or a polymer-fiber mesh, wherein the mesh in the first region and the mesh in the second region are different from each other. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 54)
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- 53. The graft collar of claim 53, wherein the graft collar is sutured around a tendon graft.
- 56. A graft collar for fixing tendon to bone in a subject, wherein said graft collar comprises a sheet of mesh comprising fibers aligned substantially perpendicular in relation to a longitudinal axis of said tendon, wherein said mesh applies compression to the graft.
- 60. A graft collar for fixing tendon to bone in a subject, wherein said graft collar comprises a sheet of mesh comprising fibers aligned substantially parallel in relation to a longitudinal axis of said tendon, wherein said mesh applies lateral tension to the graft.
- 64. A scaffold apparatus for fixing musculoskeletal soft tissue to bone in a subject, said scaffold apparatus comprising two portions, wherein each of the two portions comprising first through third phases, wherein (i) the first phase comprises a material which promotes growth and proliferation of fibroblasts, (ii) the second phase adjacent to the first phase comprises a material which promotes growth and proliferation of chondroblasts, and (iii) the third phase adjacent to the second phase comprises a material which promotes the growth and proliferation of osteoblasts.
- 77. A scaffold apparatus for fixing musculoskeletal soft tissue to bone in a subject, said scaffold apparatus comprising (i) a first phase comprising a material which promotes growth and proliferation of fibroblasts, (ii) a second phase adjacent to the first phase comprising a material which promotes growth and proliferation of chondroblasts, and (iii) a third phase adjacent to the second phase comprising a material which promotes the growth and proliferation of osteoblasts, wherein a degradable cell barrier is inserted between two adjacent ones of said first through third phases.
- 81. A scaffold apparatus for fixing musculoskeletal soft tissue to bone in a subject, said scaffold apparatus comprising (i) a first phase comprising a material which promotes growth and proliferation of fibroblasts, (ii) a second phase adjacent to the first phase comprising a material which promotes growth and proliferation of chondroblasts, and (iii) a third phase adjacent to the second phase comprising a material which promotes the growth and proliferation of osteoblasts, wherein said first phase coupled to a soft tissue graft.
- 92. A scaffold apparatus for fixing musculoskeletal soft tissue to bone in a subject, said scaffold apparatus comprising (i) a graft collar and (ii) a polymer-fiber mesh coupled to the graft collar to apply mechanical loading to the graft collar.
- 109. A scaffold apparatus for fixing musculoskeletal soft tissue to bone, said scaffold apparatus being configured to apply mechanical loading to a soft tissue graft to promote regeneration of a fibrocartilage interface between said soft tissue and said bone.
- 120. An apparatus for inducing formation of fibrocartilage, said apparatus comprising a graft collar having a hollow central portion along a longitudinal axis, wherein an outer surface of the graft collar is wrapped with a polymer-fiber mesh configured to apply mechanical loading to the graft collar.
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178. A method for making a device for inducing formation of fibrocartilage comprising:
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(a) forming a graft collar; and (b) wrapping the graft collar prepared in step (a) with a polymer-fiber mesh, to form said device. - View Dependent Claims (179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 201, 202)
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- 190. A method for inducing formation of fibrocartilage comprising enclosing a graft within a polymer-fiber mesh-wrapped graft collar configured to apply mechanical loading to the graft.
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199. An apparatus for inducing formation of fibrocartilage, said apparatus comprising a graft collar having a hollow central portion along a longitudinal axis wherein an outer surface of the graft collar is clamped by a clamp to apply mechanical loading to the graft collar.
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200. A method for inducing formation of fibrocartilage, said method comprising wrapping a polymer-fiber mesh circumferentially around a graft to apply mechanical loading to the graft.
- 203. An apparatus for inducing formation of fibrocartilage said apparatus comprising a graft and a polymer-fiber mesh wrapped circumferentially around the graft to apply mechanical loading to the graft.
Specification