OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT

• US 20100047350A1
• Filed: 08/19/2008
• Published: 02/25/2010
• Est. Priority Date: 08/19/2008
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: MCKAY, William F.
• Granted Patent: US 8,039,433 B2
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/442 Colorants, dyes
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease

Abstract

An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture; applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows the user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and implanting the porous collagen matrix at or near a target tissue site in need of bone repair.

Claims

1. An osteogenic composition for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow a user to implant the growth factor at or near the target tissue site.

2. An osteogenic composition of claim 1, wherein the growth factor and coloring agent are disposed on or in at least a surface of a biodegradable matrix so as to allow the user to see the distribution of the growth factor on or in the surface of the matrix.

3. An osteogenic composition of claim 2, wherein the color of the composition is visible to the naked eye.

4. An osteogenic composition of claim 2, wherein the coloring agent comprises a color contrasting the color of the matrix.

5. An osteogenic composition of claim 2, wherein the coloring agent comprises a color contrasting the target tissue site.

6. An osteogenic composition of claim 2, wherein (i) the growth factor comprises colorless bone morphogenic protein-2 solution;

(ii) the coloring agent comprises a dye; and

(iii) the biodegradable matrix comprises porous collagen.

7. An osteogenic composition of claim 2, wherein the biodegradable matrix releases the growth factor and coloring agent for the user to see when the matrix is compressed.

8. An osteogenic composition of claim 2, wherein the biodegradable matrix holds the growth factor and coloring agent when the matrix is in an uncompressed state.

9. An osteogenic composition of claim 2, wherein the biodegradable matrix comprises at least one of collagen, a resorbable polymer, gelatin, a resorbable ceramic or combinations thereof.

10. An osteogenic composition for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising:

a growth factor;

a coloring agent; and

a biodegradable matrix comprising a porous collagen surface, wherein upon mixing the coloring agent with the growth factor, the coloring agent imparts color to the growth factor to allow a user to see the growth factor distribution on or in the porous collagen surface.

11. An osteogenic composition of claim 10, wherein the color of the composition is visible to the naked eye.

12. An osteogenic composition of claim 10, wherein the coloring agent comprises a color contrasting the color of the matrix.

13. An osteogenic composition of claim 10, wherein the coloring agent comprises a color contrasting the target tissue site.

14. An osteogenic composition of claim 10, wherein the growth factor comprises colorless bone morphogenic protein-2 solution and the coloring agent comprises a dye.

15. An osteogenic composition of claim 14, wherein the biodegradable matrix releases the growth factor and coloring agent for the user to see when the matrix is compressed.

16. An osteogenic composition of claim 14, wherein the biodegradable matrix holds the growth factor and coloring agent when the matrix is in an uncompressed state.

17. A method for accelerating bone repair in a patient in need of such treatment, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture, wherein the coloring agent imparts color to the mixture;

applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows a user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and

implanting the porous collagen matrix at or near a target tissue site in need of bone repair.

18. A method for accelerating bone repair according to claim 17, wherein bone morphogenic protein-2 comprises a colorless solution and the coloring agent comprises a dye.

19. A method for accelerating bone repair according to claim 17, wherein the biodegradable matrix releases bone morphogenic protein-2 and the coloring agent when the matrix is compressed for the user to see.

20. A method for accelerating bone repair according to claim 17, wherein the coloring agent comprises a color contrasting the color of the matrix.