METHOD OF SURFACE PLASMON RESONANCE (SPR) TO DETECT GENOMIC DISORDERS FOR POSTNATAL DIAGNOSIS
First Claim
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1. An improved SPR biosensor chip for detecting the presence of specific DNA loss or gain in a peripheral blood sample prepared by forming a linking layer on the surface of a metal film on a glass chip and immobilizing of one or more DNA markers on the surface of the linking layer.
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Abstract
The present invention discloses using SPR technology to postnatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of subtelomere imbalances and chromosome microdeletion syndromes is also disclosed.
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16 Claims
- 1. An improved SPR biosensor chip for detecting the presence of specific DNA loss or gain in a peripheral blood sample prepared by forming a linking layer on the surface of a metal film on a glass chip and immobilizing of one or more DNA markers on the surface of the linking layer.
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