Methods and compositions for targeted single-stranded cleavage and targeted integration
First Claim
Patent Images
1. A fusion protein comprising a DNA-binding domain and at least one catalytically inactive cleavage domain or cleavage half-domain.
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.
-
Citations
13 Claims
- 1. A fusion protein comprising a DNA-binding domain and at least one catalytically inactive cleavage domain or cleavage half-domain.
Specification