DIAGNOSIS OF CARCINOMAS
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Abstract
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.
21 Citations
96 Claims
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1-72. -72. (canceled)
- 73. An isolated HE4a polypeptide having an amino acid sequence that comprises SEQ ID NO:
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89. An isolated immunogenic fragment of HE4a, the fragment having an amino acid sequence that includes at least 20 consecutive residues of SEQ ID NO:
- 11, the consecutive residues including at least one of
i) residue 71 of SEQ ID NO;
11;ii) both residues 72 and 73 of SEQ ID NO;
11; andiii) residue 101 of SEQ ID NO;
11. - View Dependent Claims (90, 91, 92)
- 11, the consecutive residues including at least one of
- 93. A posttranslationally modified HE4a polypeptide made by expressing in a cell a compatible expression vector encoding an HE4a polypeptide having an amino acid sequence that comprises SEQ ID NO:
Specification