PROCESS FOR PRODUCING SILYLATED PULLULAN AND COSMETIC PREPARATION

• US 20100048886A1
• Filed: 03/30/2007
• Published: 02/25/2010
• Est. Priority Date: 03/30/2007
• Status: Active Grant

• Current Assignee: Dainichiseika Color & Chemicals Manufacturing Company Limited
• Original Assignee: Dainichiseika Color & Chemicals Manufacturing Company Limited
• Inventors: Fukuhara, Takahiro, Izume, Masato, Niwa, Makoto, Tsuchida, Shinya, Kobayashi, Nobuyuki, Sannan, Takanori
• Granted Patent: US 9,125,837 B2
• Time in Patent Office: Days
• US Class Current: 536/123.100
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 1/08 for cheeks, e.g. rouge
• CPC Class Codes: A61Q 1/10 for eyes, e.g. eyeliner, mascara
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations
• CPC Class Codes: C08B 37/0018 Pullulan, i.e. (alpha-1,4)(alpha-1,6)-D-glucan; Derivatives thereof

Abstract

The present invention provides a process for producing silylated pullulan, which features reacting pullulan with N,O-bistrimethylsilylacetamide by using, as a reaction medium, only one of N-methyl-2-pyrrolidone and N-ethyl-2-pyrrolidone or a mixed solvent of both of them. Compared with conventional processes, the process according to the present invention can produce high-purity silylated pullulan simply, easily and efficiency.

Claims

1. A process for producing silylated pullulan, comprising:

reacting pullulan with N,O-bistrimethylsilylacetamide by using, as a reaction medium, only one of N-methyl-2-pyrrolidone and N-ethyl-2-pyrrolidone or a mixed solvent thereof.

2. The process according to claim 1, wherein toluene is used as a diluent upon production.

3. A method for purifying silylated pullulan, comprising:

dissolving silylated pullulan, which is obtainable by the process according to claim 1, in toluene and/or isopropyl alcohol,

pouring the resulting solution into methanol to precipitate the silylated pullulan, and

desolvating the precipitated silylated pullulan.

4. A method for drying silylated pullulan, comprising:

repeating once or more an operation that dries, disintegrates and re-dries silylated pullulan obtainable by the process according to claim 1.

5. An oil-based cosmetic preparation comprising silylated pullulan obtainable by the process according to claim 1.

6. A method for drying silylated pullulan, comprising:

repeating once or more an operation that dries, disintegrates and re-dries silylated pullulan obtainable by the method according to claim 3.

7. An oil-based cosmetic preparation comprising silylated pullulan obtainable by the method according to claim 3.

8. An oil-based cosmetic preparation comprising silylated pullulan obtainable by the method according to claim 4.