Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium
First Claim
1. A method for determining a condition of a region of epithelial breast tissue comprising:
- establishing a connection between a first electrode and the epithelial tissue of a breast;
placing a second electrode in contact with the surface of the breast;
establishing a signal between the first and second electrodes;
measuring an electrical property between the first and second electrode; and
determining the condition of a region of epithelial tissue based on the signal between the first and second electrode.
1 Assignment
0 Petitions
Accused Products
Abstract
A method and system are provided for determining a condition of a selected region of epithelial and stromal tissue in the human breast. A plurality of measuring electrodes are used to measure the tissue and transepithelial electropotential of breast tissue. Surface electropotential and impedance are also measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.
-
Citations
24 Claims
-
1. A method for determining a condition of a region of epithelial breast tissue comprising:
-
establishing a connection between a first electrode and the epithelial tissue of a breast; placing a second electrode in contact with the surface of the breast; establishing a signal between the first and second electrodes; measuring an electrical property between the first and second electrode; and determining the condition of a region of epithelial tissue based on the signal between the first and second electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method for determining the location of a tumor in a body comprising:
-
establishing a connection between a first electrode and the epithelial tissue of the duct of an organ; placing a second electrode at a second location on the body; establishing a signal between the first, and second electrodes; measuring an electrical property between the first and second electrodes; and determining the condition of the selected region of epithelial tissue based on the signal between the first and second electrode. - View Dependent Claims (11, 12, 13)
-
-
14. An apparatus for determining the location of a tumor in a body comprising:
-
first electrode operable for electrical communication with the epithelial tissue of the duct of an organ; a second;
electrode at a location spaced from said first electrode;means for establishing a signal between the first and second electrodes; and means for measuring at least one electrical property between the first and second electrode so as to determine the condition of the selected region of epithelial tissue based on the signal between the first and second electrode. - View Dependent Claims (15, 16, 17, 18, 19, 20)
-
-
21. An apparatus for determining the condition of an area of tissue in a body comprising:
-
first electrode operable for electrical communication with the epithelial tissue of the duct of an organ; a second electrode at a location spaced from said first electrode; a means for establishing a signal between the first and second electrodes; and a means for measuring a plurality of electrical properties between the first and second electrode so as to determine the condition of the selected region of epithelial tissue based on the pluralities of electrical properties between the first and second electrode. - View Dependent Claims (22, 23)
-
-
24. A computer-readable medium having computer-executable instructions for performing a method for determining the presence of a tumor in the human breast comprising:
-
establishing a connection between a first electrode and a region of epithelial tissue within the duct of a breast; establishing a connection between a second electrode on the surface of the breast; establishing a signal between the first and second electrodes; measuring an electrical property between the first and second electrode; and determining the presence of a tumor based on the signal between the first and second electrode.
-
Specification