METHODS OF TREATING ISCHEMIC SPASTITICY
First Claim
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1. A method of treating a spasticity or rigidity condition in a subject in need thereof comprising:
- a) isolating neural stem cells of human origin;
b) expanding in vitro the isolated neural stem cells in a dispersed adherent culture to form an expanded population of neural stem cells;
c) concentrating the expanded population of neural stem cells to form concentrated neural stem cells;
d) introducing said concentrated neural stem cells into an area of central nervous system tissue of the subject with reduced GABA-producing or glycine-producing neurons; and
e) generating GABA-producing or glycine-producing neurons in said tissue.
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Abstract
The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord.
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Citations
20 Claims
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1. A method of treating a spasticity or rigidity condition in a subject in need thereof comprising:
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a) isolating neural stem cells of human origin; b) expanding in vitro the isolated neural stem cells in a dispersed adherent culture to form an expanded population of neural stem cells; c) concentrating the expanded population of neural stem cells to form concentrated neural stem cells; d) introducing said concentrated neural stem cells into an area of central nervous system tissue of the subject with reduced GABA-producing or glycine-producing neurons; and e) generating GABA-producing or glycine-producing neurons in said tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification