CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS
First Claim
1. An isolated heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide the amino acid sequence of which has at least 95% sequence identity with amino acid residues 20-732 of SEQ ID NO:
- 111, and a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
7, and wherein the heterodimeric or multimeric receptor polypeptide binds a ligand comprising amino acid residues 27-164 of SEQ ID NO;
2.
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Accused Products
Abstract
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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Citations
21 Claims
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1. An isolated heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide the amino acid sequence of which has at least 95% sequence identity with amino acid residues 20-732 of SEQ ID NO:
- 111, and a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
7, and wherein the heterodimeric or multimeric receptor polypeptide binds a ligand comprising amino acid residues 27-164 of SEQ ID NO;
2. - View Dependent Claims (2, 3)
- 111, and a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
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4. An isolated soluble heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide the amino acid sequence of which has at least 95% sequence identity with amino acid residues 20-519 of SEQ ID NO:
- 1, and a second receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7, and wherein the soluble heterodimeric or multimeric receptor binds a ligand comprising amino acid residues 27-164 of SEQ ID NO;
2. - View Dependent Claims (5, 6, 7)
- 1, and a second receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
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8. A composition comprising:
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a soluble heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide the amino acid sequence of which has at least 95% sequence identity with amino acid residues 20-519 of SEQ ID NO;
111, and a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7; anda pharmaceutically acceptable vehicle. - View Dependent Claims (9, 10)
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11. An isolated heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide comprising amino acid residues 20-732 of SEQ ID NO:
- 111, and a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
7. - View Dependent Claims (12, 13)
- 111, and a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
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14. An isolated soluble heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide comprising amino acid residues 20-519 of SEQ ID NO:
- 111, and a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7. - View Dependent Claims (15, 16, 17, 18)
- 111, and a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
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19. A composition comprising:
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a soluble heterodimeric or multimeric receptor polypeptide comprising a first receptor polypeptide comprising amino acid residues 20-519 of SEQ ID NO;
111, and a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7; anda pharmaceutically acceptable vehicle. - View Dependent Claims (20, 21)
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Specification