METHODS AND TOPICAL FORMULATIONS COMPRISING COLLOIDAL METAL FOR TREATING OR PREVENTING SKIN CONDITIONS

• US 20100055138A1
• Filed: 06/19/2009
• Published: 03/04/2010
• Est. Priority Date: 12/20/2006
• Status: Abandoned Application

• Current Assignee: Joel Margulies, Terry Jacobs
• Original Assignee: Joel Margulies, Terry Jacobs
• Inventors: JACOBS, TERRY, MARGULIES, JOEL
• Application Number:
  US12/488,502
• Publication Number:
  US 20100055138A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/57 Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/241 Lead; Compounds thereof
• CPC Class Codes: A61K 33/242 Gold; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/50 the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• CPC Class Codes: A61K 8/02 characterised by special physical form
• CPC Class Codes: A61K 8/14 Liposomes; Vesicles
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61Q 17/00 Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/004 Aftersun preparations
• CPC Class Codes: A61Q 19/007 : Preparations for dry skin
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

In preferred embodiments, the present invention relates to compositions comprising colloidal metals and/or metals for the treatment and prevention of skin conditions and/or diseases. More specifically, the disclosed metal containing compositions are useful as antioxidants, anti-aging agents, anti-wrinkle agents, anti-peroxidation agents, antimicrobial agents, anti-inflammatory agents, pain-relieving agents, wound recovery agents, sun-screens, sunblocks, and integument and skin-supporting agents when applied to the skin/integument, or administered generally to an animal or human body.

Claims

1. A composition, comprising colloidal metal and a cosmetically suitable carrier.

2. The composition according to claim 1, further comprising metal flakes.

3. The composition according to claim 1, wherein the colloidal metal comprises metal particles having a size from about 1-200 nm in a colloidal suspension.

4. The composition according to claim 2, wherein the metallic flakes have a particle size from about 1-5 mm.

5. The composition according to claim 1, wherein the colloidal metal comprises from about 0.001-50 percent by weight of the composition.

6. The composition according to claim 1, wherein the colloidal metal comprises a metal alloy.

7. The composition according to claim 2, wherein the metal flakes comprise a metal alloy.

8. The composition according to claim 1, wherein the colloidal metal is conjugated to a molecule.

9. The composition according to claim 8, wherein the conjugated colloidal metal comprises metal particles having a size from about 1-250 nm.

10. The composition according to claim 8, wherein the said molecule is selected from the group consisting of peptides, carbohydrates, enzymes, proteins, antigens, hormones, or polysaccharides.

11. The composition according to claim 1, wherein the suitable carrier comprises a skin-penetrating carrier.

12. The composition according to claim 11, wherein the said skin-penetrating carrier is selected from the group consisting of DMSO, liposomes, lipophilic solvents, lecithin, transcutol, nanospheres, nanoshells, or rovisomes.

13. The composition according to claim 11, wherein the said skin-penetrating carrier comprises a hollow and solid lipid structure.

14. The composition according to claim 11, wherein the said skin-penetrating carrier comprises a nano-structure.

15. The composition according to claim 1, further comprising of at least one additional agent.

16. The composition according to claim 15, wherein the said at least one additional agent is selected from the group consisting of a mineral, an emollient, an antimicrobial agent, an antioxidant, an analgesic, an anti-inflammatory agent, and a sebum-reducing agent.

17. The composition according to claim 15, wherein the at least one additional agent is selected from the group consisting of a hormone, an enzyme, a peptide, a protein, a lipid, a retinoid, a vitamin a wound recovery agent, a botanical extract, a MMP inhibitor, a polysaccharide, and an antigen.

18. The composition according to claim 15, wherein the said at least one additional agent comprises an integument and skin-supporting component.

19. A method of treating and/or preventing a skin/integument condition, comprising administering to a patient in need thereof, an amount of the composition of claim 1, wherein the amount is sufficient to treat and/or prevent the skin/integument condition.

20. The method according to claim 19, wherein the mode of administration is selected from the group consisting of topical, oral, transdermal, mucosal, enteral, parenteral, or sublingual administration.