Carrier Neutralization/Modification in Antimicrobial Compositions, Articles and Methods

• US 20100055142A1
• Filed: 08/27/2009
• Published: 03/04/2010
• Est. Priority Date: 08/28/2008
• Status: Abandoned Application

• Current Assignee: Tyco Healthcare Group LP (Medtronic Plc)
• Original Assignee: Tyco Healthcare Group LP (Medtronic Plc)
• Inventors: Dowd, Brian, Mulligan, Sharon A., Vitaris, Ronald F., Shah, Chirag B., Fink, E. David, Heagle, David G.
• Application Number:
  US12/548,514
• Publication Number:
  US 20100055142A1
• Time in Patent Office: Days
• US Class Current: 424/404
• CPC Class Codes: A61F 2013/00293 anallergic or hypoallergic material
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/208 Quaternary ammonium compounds
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow

Abstract

A method of treating a substrate having a charge bias with at least one antimicrobial agent to modify the release properties of the antimicrobial agent with respect to the substrate, the method includes eliminating, mitigating, or modifying the charge bias of the substrate by applying at least one first agent to the substrate, and applying the at least one antimicrobial agent to the substrate. Related articles are also described.

Claims

1. A method of treating a substrate having a charge bias with at least one antimicrobial agent to modify the release properties of the antimicrobial agent with respect to the substrate, the method comprising:

(a) eliminating, mitigating, or modifying the charge bias of the substrate by applying at least one first agent to the substrate; and

(b) applying the at least one antimicrobial agent to the substrate.

2. The method of claim 1, wherein (a) and (b) are performed sequentially.

3. The method of claim 1, wherein (a) and (b) are performed simultaneously.

4. The method of claim 1, further comprising:

drying the substrate.

5. The method of claim 4, wherein the drying is performed subsequent to (a).

6. The method of claim 4, wherein the drying is performed subsequent to (b).

7. The method of claim 4, wherein the drying is performed subsequent to (a), and performed again subsequent to (b).

8. The method of claim 6, wherein no further treatment steps are performed subsequent to the drying.

9. The method of claim 1, wherein the charge bias is anionic, and wherein the at least one first agent is cationic.

10. The method of claim 1, wherein (a) and (b) are performed by at least one of:

padding, spraying, gravure roll, and slot coating.

11. The method of claim 1, wherein the at least one first agent and the at least one antimicrobial agent are applied to the substrate in the form of a solution.

12. The method of claim 1, further comprising shielding at least a portion of the substrate from exposure to the at least one first agent during (a), and exposing the shielded portion of the substrate during (b).

13. The method of claim 1, further comprising surface treating the substrate to associate one or more functional groups therewith.

14. The method of claim 13, wherein the functional groups comprise both anionic and cationic groups.

15. The method of claim 13, comprising surface treating the substrate with a polyampholyte.

16. The method of claim 13, wherein the surface treating comprises at least one of:

wet chemical reaction;

organosilanization;

ionized gas treatments;

UV radiation; and

tethering with an intermediary.

17. The method of claim 1, wherein the at least one first agent comprises a first fraction capable of penetrating below an outer surface of the substrate, and a second fraction interacting with an outer surface portion of the substrate.

18. The method of claim 17, wherein the at least one first agent comprises a cationic polyelectrolyte, the first fraction comprises a low molecular weight fraction of the polyelectrolyte, and the second fraction comprises a high molecular weight fraction of the polyelectrolyte.

19. The method of claim 1, wherein the substrate comprises:

particles, beads, spheres, continuous sheets, discrete sheets, foams, gels or 3-dimensional shapes.

20. The method of claim 1, wherein the substrate is formed from a material comprising:

glass, ceramic, metal or polymer.

21. The method of claim 1, wherein the substrate comprises:

natural fibers;

synthetic fibers;

or combinations thereof.

22. The method of claim 21, wherein the fibers are formed from:

cotton, cellulose, polyester, polyethylene, polypropylene, PTFE, nylon, aramid, Kevlar, chitosan, alginate, poly(ethylene terephthate), glass, ceramics, metal, acrylics, fluorocarbon, modacrylic, polyester, rubber, saran, spandex, vinal, vinyon, rayon, acetate, triacetate, protein, flax, hemp, jute, ramie, manila, kapok, wool, silk;

or combinations thereof.

23. The method of claim 21, wherein the fibers are:

woven;

non-woven;

knit;

felt;

braided;

continuous fiber or tow;

cut staple fiber;

wet laid/paper;

meltblown;

flash spun fibrillated tape;

spunbond;

needle-punched;

carded;

composite structures;

thermal bonded;

chemically bonded;

hydroentangled;

airlaid;

drylaid;

highloft;

ultrasonically bonded stitchbonded powderbonded;

or combinations thereof.

24. The method of claim 1, wherein the at least one first agent comprises:

alum;

aluminum ammonium sulfate;

polyethyleneimine;

or combinations thereof.

25. The method of claim 1, wherein the at least one first agent comprises:

a zwitterionic compound;

a polyelectrolyte;

a quaternized hydroxyethyl cellulose polymer;

a combination of cationic copolymers;

a cationic polysaccaride;

carboxymethylcellulose;

or combinations thereof.

26. The method of claim 1, wherein the at least one antimicrobial agent comprises:

a polymeric biguanide;

a cationic quaternary ammonium compound, a polymeric quaternary ammonium compound;

a polyquaternium;

a cationic antimicrobial peptide;

or combinations thereof.

27. An article comprising a substrate, the substrate comprising a surface, at least a portion of the surface having a charge bias eliminated, mitigated or modified by at least one first agent, the article further comprising at least one antimicrobial agent releasable from the portion of the surface.

28. The article of claim 27, wherein the charge bias is anionic, and wherein the at least one first agent is cationic.

29. The article of claim 27, wherein at least a portion of the surface comprises one or more functional groups associated therewith.

30. The article of claim 29, wherein the functional groups comprise both anionic and cationic groups.

31. The article of claim 27, wherein the at least one first agent comprises a first fraction capable of penetrating below an outer portion of the surface, and a second fraction interacting with the outer portion of the surface.

32. The article of claim 31, wherein the at least one first agent comprises a cationic polyelectrolyte, the first fraction comprises a low molecular weight fraction of the polyelectrolyte, and the second fraction comprises a high molecular weight fraction of the polyelectrolyte.

33. The article of claim 27, wherein the substrate comprises:

particles, beads, spheres, continuous sheets, discrete sheets, foams, gels or 3-dimensional shapes.

34. The article of claim 27, wherein the substrate is formed from a material comprising:

glass, ceramic, metal or polymer.

35. The article of claim 27, wherein the substrate comprises:

natural fibers;

synthetic fibers;

or combinations thereof.

36. The article of claim 35, wherein the fibers are formed from:

cotton, cellulose, polyester, polyethylene, polypropylene, PTFE, nylon, aramid, Kevlar, chitosan, alginate, poly(ethylene terephthate), glass, ceramics, metal, acrylics, fluorocarbon, modacrylic, polyester, rubber, Saran, spandex, vinal, vinyon, rayon, acetate, triacetate, protein, flax, hemp, jute, ramie, manila, kapok, wool, silk;

or combinations thereof.

37. The article of claim 35, wherein the fibers are:

woven;

non-woven;

knit;

felt;

braided;

continuous fiber or tow;

cut staple fiber;

wet laid/paper;

meltblown;

flash spun fibrillated tape;

spunbond;

needle-punched;

carded;

composite structures;

thermal bonded;

chemically bonded;

hydroentangled;

airlaid;

drylaid;

highloft;

ultrasonically bonded stitchbonded powderbonded;

or combinations thereof.

38. The article of claim 27, wherein the at least one first agent comprises:

alum;

aluminum ammonium sulfate;

polyethyleneimine;

or combinations thereof.

39. The article of claim 27, wherein the at least one first agent comprises:

a zwitterionic compound;

a polyelectrolyte;

a quaternized hydroxyethyl cellulose polymer;

a combination of cationic copolymers;

a cationic polysaccaride;

carboxymethylcellulose;

or combinations thereof.

40. The article of claim 27, wherein the at least one antimicrobial agent comprises:

a polymeric biguanide;

a cationic quaternary ammonium compound, a polymeric quaternary ammonium compound;

a polyquaternium;

a cationic antimicrobial peptide;

or combinations thereof.

41. A wound dressing formed from the article of claim 27.