Pharmaceutical Compositions Including Low Dosages of Desmopressin
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Accused Products
Abstract
The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 μg desmopressin and a pharmaceutically acceptable carrier. The present invention is also directed to a pharmaceutical composition comprising desmopressin and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is effective to establish a steady plasma/serum desmopressin concentration in the range of from about 0.1 picograms desmopressin per mL plasma/serum to about 10.0 picogram desmopressin per mL plasma/serum. Articles of manufacture and methods of using the above invention are also disclosed.
70 Citations
34 Claims
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1-18. -18. (canceled)
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19. A nasal spray for inducing voiding postponement in a patient while reducing the risk that the patient develops hyponatremia, the nasal spray comprising 0.1 μ
- g to about 2 μ
g desmopressin, the nasal spray being formulated to establish in the bloodstream of the patient no more than about 2 ng/kg of desmopressin, being effective to produce an antidiuretic effect in the patient lasting for no more than about 6 hours, and being effective to produce a plasma/serum desmopressin concentration up to a maximum of about 10.0 picograms desmopressin per ml plasma/serum. - View Dependent Claims (20, 21, 22, 23, 24)
- g to about 2 μ
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25. An article of manufacture for inducing voiding postponement in a patient while reducing the risk that the patient develops hyponatremia comprising
a dispenser which delivers a pharmaceutical composition comprising 0.1 μ - g to about 2 μ
g desmopressin as a spray for intranasal administration, the composition being formulated to establish in the bloodstream of the patient no more than about 2 ng/kg of desmopressin, being effective to produce an antidiuretic effect in the patient lasting for no more than about 6 hours, and being effective to produce a plasma/serum desmopressin concentration up to a maximum of about 10.0 picograms desmopressin per ml plasma/serum. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34)
- g to about 2 μ
Specification