METHOD OF TREATING RAS ASSOCIATED CANCER
First Claim
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1. A method of treating a Ras associated cancer in a mammal comprising:
- (i) determining the presence of a mutation in a RAS gene in a cancer in a mammal having a Ras associated cancer; and
(ii) administering to said mammal an effective amount of a compound of Formula I;
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Abstract
New methods of treating Ras associated cancer, and especially for treating cancer that is resistant or refractory to other treatment methods, including resistant or refractory to treatment with C225 and/or CPT-11, are provided. The new methods employ PEG-conjugated 7-ethyl-10-hydroxycampothecin, alone, or in combination with other art-known anticancer agents or modalities.
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33 Claims
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1. A method of treating a Ras associated cancer in a mammal comprising:
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(i) determining the presence of a mutation in a RAS gene in a cancer in a mammal having a Ras associated cancer; and (ii) administering to said mammal an effective amount of a compound of Formula I; - View Dependent Claims (2, 3, 5, 6, 7, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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4. The method of claim 4, wherein L is glycine.
- 8. The method of claim 8, wherein (n) is from about 114 to about 239.
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31. A method of treating a Ras-associated cancer in a mammal, comprising administering an effective amount of a compound of Formula I to said mammal:
- 32. A method of treating a Ras associated cancer in a mammal, comprising administering to said mammal a polymeric conjugate of a 7-ethyl-10-hydroxycamptothecin or a pharmaceutically acceptable salt thereof.
Specification