CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA
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Abstract
An invention relating to therapeutic pharmacological agents and methods to chemically induce intracellular hyperthermia and/or free radicals for the diagnosis and treatment of infections, malignancy and other medical conditions. The invention relates to a process and composition for the diagnosis or killing of cancer cells and inactivation of susceptible bacterial, parasitic, fungal, and viral pathogens by chemically generating heat, and/or free radicals and/or hyperthermia-inducible immunogenic determinants by using mitochondrial uncoupling agents, especially 2,4 dinitrophenol and, their conjugates, either alone or in combination with other drugs, hormones, cytokines and radiation.
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Citations
63 Claims
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1-54. -54. (canceled)
- 55. A method for inducing intracellular hyperthermia in a subject comprising the step of administering an amount of a mitochondrial uncoupling agent sufficient to the subject to thereby induce whole body intracellular hyperthermia in the subject, wherein the induced intracellular hyperthermia in the subject is sufficient to treat a cancer in the subject
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