×

SPECIFIC BINDING PROTEINS AND USES THEREOF

  • US 20100056762A1
  • Filed: 02/18/2009
  • Published: 03/04/2010
  • Est. Priority Date: 05/11/2001
  • Status: Abandoned Application
First Claim
Patent Images

1. An isolated antibody capable of binding EGFR on tumors containing amplifications of the EGFR gene, wherein cells of said tumors contain multiple copies of the EGFR gene, and on tumors that express the truncated version of the EGFR receptor de2-7, wherein said antibody does not bind to the de2-7 EGFR junctional peptide consisting of the amino acid sequence of SEQ ID NO:

  • 13, wherein said antibody binds to an epitope within the sequence of residues 287-302 (SEQ ID NO;

    14) of human wild-type EGFR, and wherein said antibody does not comprise a heavy chain variable region sequence having the amino acid sequence set forth in SEQ ID NO;

    2 and does not comprise a light chain variable region sequence having the amino acid sequence set forth in SEQ ID NO;

    4.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×