IMPLANTABLE BIOSENSOR AND SENSOR ARRANGEMENT

• US 20100056888A1
• Filed: 08/13/2009
• Published: 03/04/2010
• Est. Priority Date: 08/27/2008
• Status: Active Grant

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Inventors: SKERL, Olaf, Urbaszek, Albrecht, Czygan, Gerald
• Granted Patent: US 8,323,193 B2
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2560/0261 using hydrostatic pressure
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive

Abstract

An implantable biosensor, which comprises a measuring (or first) chamber filled with the test fluid, which is able to convert a change of the concentration of a predetermined analyte or ion type into a change of a physical variable. To this end, the measuring chamber is closed by at least one membrane, which is permeable to the analyte or ion type and impermeable to the test fluid. In addition, the biosensor is equipped with at least one microacoustic sensor, which is operatively connected to the test fluid such that it can detect the physical variable that changes with the concentration of the analyte or ion type. Further relates to a sensor arrangement comprising at least one such implantable biosensor, the arrangement including a polling system that is wirelessly coupled to the biosensor.

Claims

1. An implantable biosensor (2) comprising:

a test fluid (104;

204;

304);

a first chamber (102;

202;

302) filled with the test fluid (104;

204;

304);

wherein the test fluid (104;

204;

304) is configured to convert a change of a concentration of a predetermined analyte or ion type into a change of a physical variable;

at least one membrane (103;

203;

303);

wherein the first chamber (102;

202;

302) is closed by the at least one membrane (103;

203;

303);

wherein the at least one membrane (103;

203;

303) is permeable to the predetermined analyte or ion type and impermeable to the test fluid (104;

204;

304); and

,

at least one microacoustic sensor (105, 107;

205, 207;

305), which is operatively connected to the test fluid (104;

204;

304) such that it can detect the change of the physical variable that changes with the change of the concentration of the predetermined analyte or ion type.

2. The implantable biosensor (2) according to claim 1, further comprising:

a second chamber (106) not filled with the test fluid (104);

a first microacoustic sensor (105) selected from the at least one microacoustic sensor (105, 107;

205, 207;

305) wherein said first microacoustic sensor (105) is accommodated in the first chamber (102); and

,

a second microacoustic sensor (107) selected from the at least one microacoustic sensor (105, 107;

205, 207;

305) wherein said second microacoustic sensor (107) is accommodated in the second chamber (106) and configured to detect temperature.

3. The implantable biosensor (2) according to claim 2, wherein the first microacoustic sensor (105) can detect a viscosity of the test fluid (104).

4. The implantable biosensor (2) according to claim 3, wherein the test fluid (104) is configured to convert the change of the concentration of an analyte into a change of the viscosity thereof.

5. The implantable biosensor (2) according to claim 3, wherein the test fluid (104) is configured to convert the change of the concentration of glucose into a change of the viscosity thereof.

6. The implantable biosensor (2) according to claim 1, further comprising:

a second chamber (206) not filled with the test fluid (204);

a first pressure measuring membrane (210);

wherein the first chamber (202) and said second chamber (206) are separated from each other at least in some sections by the first pressure measuring membrane (210) wherein said first pressure measuring membrane (210) is configured to deform in an event of a pressure difference between said first chamber (202) and said second chamber (206);

a second pressure measuring membrane (211);

wherein the second chamber (206) is separated from a surrounding area at least in some sections by the second pressure measuring membrane (211) that is configured to deform in an event of a pressure difference of the second chamber (206) relative to the surrounding area;

a microacoustic sensor (205) selected from the at least one microacoustic sensor (105, 107;

205, 207;

305) wherein said microacoustic sensor (205) is accommodated in the second chamber (206); and

,

wherein the microacoustic sensor (205) is operatively connected to the first and second pressure measuring membranes (210, 211) such that the microacoustic sensor (205) is configured to detect deformations thereof.

7. The implantable biosensor (2) according to claim 6, wherein the microacoustic sensor (205) is configured as a bendable element that is mechanically coupled to the first and/or second pressure measuring membrane (210, 211).

8. An implantable biosensor (2) according to claim 6, further comprising:

a further microacoustic sensor accommodated in the second chamber (206) and configured to detect temperature.

9. An implantable biosensor (2) according to claim 6, wherein the test fluid (204) is configured to convert the change of the concentration of an analyte or ion type into a change of a volume of the test fluid.

10. An implantable biosensor (2) according to claim 6, wherein the test fluid (204) is configured to convert the change of the concentration of glucose or ion type into a change of a volume of the test fluid.

11. The implantable biosensor (2) according to claim 1, further comprising:

a second chamber (206) not filled with the test fluid (204);

a first pressure measuring membrane (210);

wherein said first chamber (202) and said second chamber (206) are separated from each other by the first pressure measuring membrane (210) wherein said first pressure measuring membrane (210) is configured to deform in an event of a pressure difference between said first chamber (202) and said second chamber (206);

a second pressure measuring membrane (211);

wherein the second chamber (206) is separated from a surrounding area by the second pressure measuring membrane (211) that is configured to deform in an event of a pressure difference of the second chamber (206) relative to the surrounding area;

a first microacoustic sensor (205) and a second microacoustic sensor (207) selected from the at least one microacoustic sensor (105, 107;

205, 207;

305) wherein said first and second microacoustic sensor (205;

207) are both accommodated in the second chamber (206);

wherein the first microacoustic sensor (205) is operatively connected to the first pressure measuring membrane (210) and configured to detect deformation thereof, and,

wherein the second microacoustic sensor (207) is operatively connected to the second pressure measuring membrane (211) and configured to detect deformation thereof.

12. The implantable biosensor (2) according to claim 11, wherein the first and/or second microacoustic sensor (205, 207) is configured as a bendable element that is mechanically coupled to the first and/or second pressure measuring membrane (210, 211).

13. An implantable biosensor (2) according to claim 11, further comprising:

a further microacoustic sensor accommodated in the second chamber (206) and configured to detect temperature.

14. The implantable biosensor (2) according to claim 1, further comprising:

at least two electrodes (310, 311) that are placed in the first chamber (302) in contact with the test fluid (304);

a microacoustic sensor (305) selected from the at least one microacoustic sensor (105, 107;

205, 207;

305) wherein the microacoustic sensor (305) is connected to the at least two electrodes (310, 311); and

,

wherein the microacoustic sensor (305) is configured to detect conductivity of the test fluid (304) with the at least two electrodes (310, 311).

15. The implantable biosensor (2) according to claim 14, further comprising:

a second chamber (306) not filled with the test fluid (304);

wherein the at least two electrodes (310, 311) that are placed in the first chamber (302) and the microacoustic sensor (305) is accommodated in the second chamber (306).

16. An implantable biosensor (2) according to claim 1, wherein the test fluid (104;

204;

304) is a hydrogel.

17. A sensor arrangement (1) comprising at least one implantable biosensor (2) according to claim 1, further comprising:

a polling system (3) that is wirelessly coupled to the at least one implantable biosensor (2).

18. The sensor arrangement (1) according to claim 17, further comprising:

a medical device (4); and

,

wherein the polling system (3) is integrated into the medical device (4).

19. The sensor arrangement (1) according to claim 18, further comprising:

a home monitoring system (8); and

,

wherein the medical device (4) is coupled to the home monitoring system (8).