DEVICES AND SYSTEMS FOR LOCAL DELIVERY OF INOTROPIC AGENTS TO THE EPICARDIUM
First Claim
1. An epicardial patch for delivery of a positive inotropic agent to the heart of a patient, comprising:
- a backing layer which is substantially impermeable to the positive inotropic agent; and
a drug release layer attached to the backing layer and comprising the positive inotropic agent and a polymeric membrane material, which, upon placement of the epicardial patch onto a portion of the epicardial surface of the heart, the polymeric membrane material provides controlled release of the positive inotropic agent to the epicardium to a region of the myocardium and in an amount effective to increase contractility,wherein at least one of the backing layer or the drug release layer comprises a tissue coupling portion for affixing the epicardial patch to an area of the epicardial surface, andwherein the epicardial patch is dimensioned and compliant to substantially avoid impeding myocardial functionality when affixed to the area of the epicardial surface.
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Accused Products
Abstract
Devices and methods are provided for delivery of a positive inotropic agent to the heart of a patient in need thereof. An epicardial patch includes (i) a backing layer which is impermeable to the positive inotropic agent; and (ii) a drug release layer attached to the backing layer and including the positive inotropic agent and a polymeric membrane material. The polymeric membrane material provides controlled release of the positive inotropic agent to the epicardium to a region of the myocardium and in an amount effective to increase contractility. At least one of the backing layer or the drug release layer includes a tissue coupling portion for affixing the epicardial patch to an area of the epicardial surface. The epicardial patch is dimensioned and compliant to substantially avoid impeding myocardial functionality when affixed to the area of the epicardial surface.
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Citations
30 Claims
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1. An epicardial patch for delivery of a positive inotropic agent to the heart of a patient, comprising:
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a backing layer which is substantially impermeable to the positive inotropic agent; and a drug release layer attached to the backing layer and comprising the positive inotropic agent and a polymeric membrane material, which, upon placement of the epicardial patch onto a portion of the epicardial surface of the heart, the polymeric membrane material provides controlled release of the positive inotropic agent to the epicardium to a region of the myocardium and in an amount effective to increase contractility, wherein at least one of the backing layer or the drug release layer comprises a tissue coupling portion for affixing the epicardial patch to an area of the epicardial surface, and wherein the epicardial patch is dimensioned and compliant to substantially avoid impeding myocardial functionality when affixed to the area of the epicardial surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A drug delivery system for delivery of a positive inotropic agent to the heart of a patient comprising:
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a reservoir device housing a liquid formulation which comprises an inotropic agent; an implantable epicardial patch which is affixable to an area of the epicardial surface of the heart, the epicardial patch comprising a backing layer which is impermeable to the inotropic agent; and a catheter having a first end connected to the reservoir device, an opposed second end connected to the epicardial patch, the tube being effective to transport the liquid formulation from the reservoir to the epicardial patch, wherein the patch provides controlled release of the positive inotropic agent to a region of the myocardium and in an amount effective to increase contractility. - View Dependent Claims (22, 23, 24, 25, 26)
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27. A method of administering a positive inotropic agent to a heart of a patient in need thereof comprising:
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providing an implantable epicardial patch which is affixable to an area of an epicardial surface of the heart, the epicardial patch comprising a backing layer which is impermeable to the positive inotropic agent; placing the epicardial patch onto the epicardial surface of the heart; and releasing the positive inotropic agent from the epicardial patch to the epicardium to a region of the myocardium in an amount effective to increase contractility. - View Dependent Claims (28, 29, 30)
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Specification