METHOD AND APPARATUS FOR CONTROLLING THE COMPOUNDING OF A PHARMACEUTICAL ADMIXTURE

• US 20100057264A1
• Filed: 11/13/2009
• Published: 03/04/2010
• Est. Priority Date: 12/03/1999
• Status: Abandoned Application

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Lewis, Robert E., Kircher, Joseph J., Czarny, Ronald W., Miller, Joe A., Nitzki-George, Diane M.
• Application Number:
  US12/618,348
• Publication Number:
  US 20100057264A1
• Time in Patent Office: Days
• US Class Current: 700/285
• CPC Class Codes: B01F 2101/2202 Mixing compositions or mixers in the medical or veterinary field
• CPC Class Codes: B01F 33/8442 using a computer for controlling information and converting it in a formula and a set of operation instructions, e.g. on the point of sale
• CPC Class Codes: B01F 33/846 using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles
• CPC Class Codes: B01F 33/848 using data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the dispensing and mixing operations
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 70/40 relating to drugs, e.g. their side effects or intended usage
• CPC Class Codes: H01L 21/8222 Bipolar technology
• CPC Class Codes: H01L 23/485 consisting of layered constructions comprising conductive layers and insulating layers, e.g. planar contacts H01L23/4821, H01L23/4822, H01L23/4824, H01L23/4825 take precedence; materials H01L23/532, bond pads H01L24/02, bump connectors H01L24/10
• CPC Class Codes: H01L 27/0823 including vertical bipolar transistors only
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/0002 Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
• CPC Class Codes: Y10T 436/25 including sample preparation
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A method of controlling the compounding of a prescribed admixture, the method performed by a computer under control of a computer program, the method including: inputting the prescribed admixture; determining if a concentration of the prescribed admixture is within an allowed range; and if the concentration is within the allowed range, choosing which of at least two of the following compounding setups to employ (i) a high and a low flow compounding setup for the prescribed admixture, (ii) a low flow compounding setup for the prescribed admixture, and (iii) a high flow compounding setup for the prescribed admixture.

Claims

1. A method of controlling the compounding of a prescribed admixture, the method performed by a computer under control of a computer program, the method comprising:

inputting the prescribed admixture;

determining if a concentration of the prescribed admixture is within an allowed range; and

if the concentration is within the allowed range, choosing which of at least two of the following compounding setups to employ (i) a high and a low flow compounding setup for the prescribed admixture, (ii) a low flow compounding setup for the prescribed admixture, and (iii) a high flow compounding setup for the prescribed admixture.

2. The method of controlling the compounding of a prescribed admixture of claim 1, further comprising inputting at least one of (a) patient identification information and (b) patient specific data.

3. The method of controlling the compounding of a prescribed admixture of claim 1, further comprising determining a range of acceptable concentration levels for a plurality of ingredients of the prescribed admixture.

4. The method of controlling the compounding of a prescribed admixture of claim 1, further comprising (a) overriding an alert or (b) rejecting the prescribed admixture if the concentration is outside the allowed range.

5. The method of controlling the compounding of a prescribed admixture of claim 1, which includes determining a number of at least one of (a) compatibility groups and (b) rinses if at least one of setup (i) and setup (iii) is chosen.

6. The method of controlling the compounding of a prescribed admixture of claim 1, which includes determining if lipids are present in the prescribed admixtures.

7. The method of controlling the compounding of a prescribed admixture of claim 6, wherein determining if lipids are present includes determining if lipids are included in a final bag.

8. The method of controlling the compounding of a prescribed admixture of claim 7, wherein if lipids are included in the final bag, determining if the lipids are required to be first in the final bag.

9. The method of controlling the compounding of a prescribed admixture of claim 6, wherein if lipids are present, determining if lipid haze is a concern.

10. The method of controlling the compounding of a prescribed admixture of claim 9, wherein if lipid haze is a concern, not preparing the prescribed admixture.

11. The method of controlling the compounding of a prescribed admixture of claim 1, which includes applying a rule of mixing a total parenteral nutrition (“

TPN”

) solution.

12. The method of controlling the compounding of a prescribed admixture of claim 11, wherein the rule is selected from the group consisting of (i) phosphate salts are added before calcium salts;

(ii) a determination of calcium phosphate solubility is made based on a volume of solution in the TPN bag at the time calcium is added;

(iii) unless lipids are required as a last additive, calcium is to be the last additive to the TPN bag; and

(iv) compatibility groups are numbered sequentially to coincide with an order of mixing unless specific exceptions are identified.

13. The method of controlling the compounding of a prescribed admixture of claim 6, which includes calculating solubilities with or without a volume of the lipids.

14. The method of controlling the compounding of a prescribed admixture of claim 1, which includes determining if a total volume of the prescribed admixture, excluding lipids, is more than a funnel volume.

15. The method of controlling the compounding of a prescribed admixture of claim 14, wherein if the total volume is more than the funnel volume, transferring instructions to a compounder if a source rinse of a base of the prescribed admixture can be held for a rinse in an acceptable sequence.

16. A method of controlling the compounding of a prescribed admixture, the method performed by a computer under the control of a computer program, the method comprising:

inputting the prescribed admixture;

determining if a concentration of the prescribed admixture is within an allowed range;

if the concentration is within the allowed range, determining if lipids are present in the prescribed admixture; and

if lipids are present, determining if the lipids are required to be contained in a final bag.

17. The method of controlling the compounding of a prescribed admixture of claim 16, wherein if lipids are required to be contained in a final bag, and lipid haze is a concern, not preparing the prescribed admixture.

18. A method of controlling the compounding of a prescribed admixture, the method performed by a computer under the control of a computer program, the method comprising:

inputting the prescribed admixture;

choosing which of at least two of the following compounding setups to employ (i) a high and a low flow compounding setup for the prescribed admixture, (ii) a low flow compounding setup for the prescribed admixture, and (iii) a high flow compounding setup for the prescribed admixture determining if a concentration of the prescribed admixture is within an allowed range; and

altering the control of the compounding under the chosen setup based upon whether lipids are present in the prescribed admixture.

19. The method of controlling the compounding of a prescribed admixture of claim 18, which includes determining if a concentration of the prescribed admixture is within an allowed range and performing the choosing step if the concentration is within the allowed range.

20. The method of controlling the compounding of a prescribed admixture of claim 18, altering the control of the compounding under the chosen setup based upon whether lipids are present in the prescribed admixture includes determining if the lipids are included in a final bag.