POLY TLR ANTAGONIST
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Accused Products
Abstract
Mycobacterium w or its components are found to have poly TLR antagonistic activity to induced TLRs by varieties of TLR ligands. The induced TLR against which inhibitory effect is seen includes TLR 3, 4, 5, 6, 7, 8, 9. They also display antagonistic activities to effects of TLR ligands. They are also useful in management of diseases wherein TLRs are over expressed, like sepsis, multiple sclerosis, optic neuritis, Chronic obstructive pulmonary diseases multiple myeloma etc.
4 Citations
35 Claims
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1-29. -29. (canceled)
- 30. A method for treating a disease characterized by over expression of a toll-like receptor (TLR) comprising administering to a patient in need thereof an effective amount of Mycobacterium w and/or constituents of Mycobacterium w.
Specification